laboratories

Group Leader: Carmen GianfraniTopics: Immunity and Infection   MIIN LAB, is a mucosal immunologist interested in studying the interaction between food proteins and gastrointestinal immune system. Her research is mainly focused on the disregulation of immune tolerance to wheat gluten and on defining immunomodulatory strategies to recover the oral tolerance to gluten in celiac disease…

Group Leader : Ferdinando FebbraioTopics : Biochemistry   The studies of proteins, and recently also nucleic acids, are oriented to the development of their biotechnological applications such as molecular markers, bioreceptors in biosensors and bio-drugs.   Key Pubblications G.P. Cetrangolo, C. Gori, J. Rusko, S. Terreri, G. Manco, A. Cimmino, F. Febbraio, Determinationof Picomolar Concentrations…

Group Leader : Alberto LuiniTopics : Advanced Morphology, Biochemistry, Cell and molecular biology, Pharmacology   Main theme We are interested in the morpho-functional organization and the regulation of the intracellular membrane transport apparatus. The emphasis is on developing strategies, cellular models and technology (including imaging and systems biology approaches) for the analysis of whole live…

Group Leader : Emilia VitaleTopics: Neurobiology   The NeurOMICS lab is dedicated to advancing the understanding of the complexities of dementia and to generating new biological insights into the development of personalized therapeutic strategies for neurodegenerative diseases and dementia. Dementia is an enormous burden for patients, patients’ families and the health-care system. Dementia is not…

Group Leader : Francesca Maria PisaniTopics: Biochemistry   The goal of our research is to dissect structural/functional relationships of enzymes and proteins involved in DNA replication and genome stability maintenance. In the past our activity was focused on the biochemical characterization of DNA replication factors from Archaea. The archaeal DNA replication machinery, being a simplified…

Group Leader: Seetharaman ParashuramanTopics : Advanced Morphology, Biochemistry, Cell and molecular biology, Pharmacology   Organization, spatial and temporal, is a fundamental feature of life. The form and function of an organism is determined by the organization of its molecular constituents. The last decade had exploded with “omics” technologies that have given us the parts list…

Group leader : Stefania MariggiòTopics : Advanced Morphology, Cell and Molecular Biology, Pharmacology   Increasing evidence indicates that G-protein-coupled receptors (GPCRs) are ‘druggable’ targets in cancer treatment and prevention. Our research focuses on the lysophospholipid receptors, as members of the GPCR superfamily. LPAR1 and GPR55 are interesting candidates, as they have roles in the regulation…

Group Leader : Giuseppe MancoTopics : Biochemistry, Pharmacology Main research line is the study of the structure-function relationship in enzymes from the viewpoint of understanding the determinants that underlay (thermal)stability and the molecular processes which control the substrate recognition, enzyme inhibition and enzyme catalysis. The tasks are approached mainly by studying enzymes from (hyper)thermophilic sources, mainly from Archaea and…

Group Leader: Paola ItalianiTopics: Immunity and InfectionKeywords: innate immunity, Inflammation, nanosafety, monocytes/macrophages. Dr. Paola Italiani, head of the laboratory of Innate Immunity, Inflammation and Nanosafety at IBBC, is an experimental immunologist with twenty years’ experience in innate immunity and inflammation and pharmacology, in project management in academy and in collaboration with industry, and in higher…