The IBBC “Protein structure/function and biotechnology Group” comprises five laboratories (Corda, de Pascale, Febbraio, Manco, Pisani) dedicated to the study of different and complementary aspects of protein structure, function and applications. The Group is focused on the following aspects:
1. Assessing the structure-function relationship in proteins and enzymes through in vitro biochemical and biophysical studies including the resolution of 3D structures, the identification of post-translational modifications and protein-protein interactions.
2. Identifying mutations that underlie diseases and conceive pharmacological therapeutic approaches by, screening with functional assays, enzyme mechanism analyses, inhibitory studies, and bioinformatics.
3. Studying cell (sub)proteoma and its variation under different conditions by mass spectrometry, including protein interactions with other cellular components (RNA, DNA, lipids, carbohydrates, metabolites)
4. Developing applications of enzymes and proteins in different fields, also by modifying them with advanced techniques of protein engineering.