laboratories

The Computational Biology Unit has been established through the joint efforts of the Informatic Engineering Department at the Federico II University in Naples and the Molecular and Cell Biology group at the CNR, IBBC, Naples. It is led by Prof. Antonio Rinaldi (Federico II University) and Alberto Luini (CNR) The Unit develops methods for the…

Group Leader: Silvia MandilloTopic: Neurobiology   We conduct in-depth behavioral analysis of inbred and mutant mouse strains to develop genetic models of neurodegenerative and psychiatric diseases (e.g. Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Myotonic Dystrophy type 1, Schizophrenia, Autism Spectrum Disorders, anxiety and depression). We study motor and cognitive functions as well as social and emotional…

Group Leader:  Stefano Farioli VecchioliTopic: Neurobiology Main Topics Study of the role of the cell cycle mediators in the regulation of adult neurogenesis through the use of genetically modified mouse models. Very recently we are analyzing a new murine strain in which the deletion of the p21 gene (one of the main cell cycle regulators)…

Group Leader : Francesca De SantaTopic: Muscle Biology and PathologyKEYWORDS: Skeletal muscle regeneration; Duchenne Muscular Dystrophy; Inflammation; Macrophages The general focus of our research activity is the role of inflammation in regeneration of dystrophic skeletal muscles.Muscular dystrophies are a group of genetic disorders associated with mutations of genes that regulate myofiber integrity. The most common…

Group Leader: Fabiola MorettiTopics: Molecular oncology, Muscle biology and pathology Our research activity is mainly within the oncology field. Her interest is.related to the mechanisms that regulate cell response to stress signals, mostly those derived from DNA damage. Furthermore, the involvement of hormones in these processes is being investigated. Recent research has demonstrated the role…

Group Leader : Silvia MiddeiTopic : Neurobiology Our research investigates how brain networks work and how they are associated with both normal functions, in particular memory and social behavior, and breakdown that lead to brain disorders.Our studies aim to assess brain activation, synaptic plasticity and the underlying neurobiological processes in transgenic mice for Alzheimer’s Disease…

Group Leader: Maurizia CarusoTopics: Muscle Biology and PathologyKeywords: Muscle metabolism, Cell cycle regulators, muscular dystrophy   A long-standing interest in our lab is centered on the cross-talk between cell cycle regulation and the differentiation program of skeletal muscle stem cells, which are responsible of post-natal muscle growth and regeneration. A specific attention is given to the…

Group Leader: Felice TironeTopic: Neurobiology, Molecular Oncology, Muscle biologyKEYWORDS: Adult neurogenesis, neurogenic stimuli, gene therapy   Since more than a decade Felice Tirone and his laboratory are studying the dynamics of adult neurogenesis in the two neurogenic brain niches that continue to generate new neurons during adulthood, i.e., the dentate gyrus of the hippocampus and…

Group Leader: Francesca RubertiTopic : Neurobiology     Non-coding RNAs and in particular microRNAs tunes brain cell differentiation and synaptic development and modulates brain functions such as synaptic plasticity, memory formation and behavioral performance.Our research aims to identify long noncoding RNAs (lncRNAs) and/or microRNAs as well as their interactions, and to investigate their roles in…

Group Leader: Giovina RubertiTopics: Molecular oncology and pathology, Immunity and InfectionKey words: Cancer biology, Schistosome biology, target and drug discovery   Our laboratory is active in the fields of cancer biology and Schistosoma mansoni biology. By developing model systems and investigating complex biological processes we aim to identify targets and molecules relevant for unmet medical needs: cancer…