laboratories

Group Leader: Carla Petrellacarla.petrella@cnr.itKey words: preclinical pharmacology of the gastrointestinal tract, gut-microbiota-brain axis, biomarkers, pediatric pathologies, cancer My research activity focuses mainly on two areas: Study of the role of the gut-brain axis and the microbiota in mouse models of inflammation and stress. In recent years, with colleagues from the institute (Dr Stefano Farioli-Vecchioli, Dr.…

Group Leader: Marco Fiore marco.fiore@cnr.itKey words: alcohol, addiction, FAS, FASD, infants, preterm, newborn, adolescent, NGF, BDNF, oxidative stress This research focuses on understanding the neurobiological mechanisms underlying Alcohol Use Disorders (AUD) and their interplay with pediatric syndromes, including Fetal Alcohol Spectrum Disorders (FASD) and other neurodevelopmental conditions. The lab employs a multidisciplinary approach, integrating molecular biology,…

The Computational Biology Unit has been established through the joint efforts of the Informatic Engineering Department at the Federico II University in Naples and the Molecular and Cell Biology group at the CNR, IBBC, Naples. It is led by Prof. Antonio Rinaldi (Federico II University) and Alberto Luini (CNR) The Unit develops methods for the…

Group Leader: Silvia MandilloTopic: Neurobiology   We conduct in-depth behavioral analysis of inbred and mutant mouse strains to develop genetic models of neurodegenerative and psychiatric diseases (e.g. Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Myotonic Dystrophy type 1, Schizophrenia, Autism Spectrum Disorders, anxiety and depression). We study motor and cognitive functions as well as social and emotional…

Group Leader:  Stefano Farioli VecchioliTopic: Neurobiology Main Topics Study of the role of the cell cycle mediators in the regulation of adult neurogenesis through the use of genetically modified mouse models. Very recently we are analyzing a new murine strain in which the deletion of the p21 gene (one of the main cell cycle regulators)…

Group Leader : Francesca De SantaTopic: Muscle Biology and PathologyKEYWORDS: Skeletal muscle regeneration; Duchenne Muscular Dystrophy; Inflammation; Macrophages The general focus of our research activity is the role of inflammation in regeneration of dystrophic skeletal muscles.Muscular dystrophies are a group of genetic disorders associated with mutations of genes that regulate myofiber integrity. The most common…

Group Leader: Fabiola MorettiTopics: Molecular oncology, Muscle biology and pathology Our research activity is mainly within the oncology field. Her interest is.related to the mechanisms that regulate cell response to stress signals, mostly those derived from DNA damage. Furthermore, the involvement of hormones in these processes is being investigated. Recent research has demonstrated the role…

Group Leader : Silvia MiddeiTopic : Neurobiology Our research investigates how brain networks work and how they are associated with both normal functions, in particular memory and social behavior, and breakdown that lead to brain disorders.Our studies aim to assess brain activation, synaptic plasticity and the underlying neurobiological processes in transgenic mice for Alzheimer’s Disease…

Group Leader: Maurizia CarusoTopics: Muscle Biology and PathologyKeywords: Muscle metabolism, Cell cycle regulators, muscular dystrophy   A long-standing research interest in our lab has been focused on the crosstalk between cell cycle regulation and the differentiation program of skeletal muscle stem cells, with specific attention to the role of D-type cyclins in these processes. In past…

Group Leader: Felice TironeTopic: Neurobiology, Molecular Oncology, Muscle biologyKEYWORDS: Adult neurogenesis, neurogenic stimuli, gene therapy   Since more than a decade Felice Tirone and his laboratory are studying the dynamics of adult neurogenesis in the two neurogenic brain niches that continue to generate new neurons during adulthood, i.e., the dentate gyrus of the hippocampus and…