Alcohol Use Disorders and Pediatric Syndromes – Neurobiology and Oxidative Stress

Giovanna Coriale, Gemma Battagliese, Fabiola Pisciotta, Maria Luisa Attilia, Raffaella Porrari, Francesca De Rosa, Mario Vitali, Valentina Carito, Marisa Patrizia Messina, Antonio Greco, Fiore Marco and Mauro Ceccanti. Behavioral responses in people affected by alcohol use disorder and psychiatric comorbidity: correlations with addiction severity. Ann Ist Super Sanità 2019 | Vol. 55, No. 2: 131-142. DOI: 10.4415/ANN_19_02_05

Vittorio D’Aguanno, Massimo Ralli, Marco Artico, Francesca Yoshie Russo, Alfonso Scarpa, Marco Fiore, Paola Tirassa, Cinzia Severini, Marco de Vincentiis, Antonio Greco. Systemic Amyloidosis: a Contemporary Overview. Clinical Reviews in Allergy & Immunology. 2020, 59(3), pp. 304-322. DOI: 10.1007/s12016-019-08759-4

Triaca V, Carito V, Fico E, Rosso P, Fiore M, Ralli M, Lambiase A, Greco A, Tirassa P. Cancer stem cells-driven tumor growth and immune escape: the Janus face of neurotrophins. Aging (Albany NY). 2019 Dec 8;11. doi: 10.18632/aging.102499

Ciafrè S., Ferraguti G., Tirassa P., Ralli M., Greco A., Chaldakov GN., Rosso P., Messina MP, Carito V., Tarani L., Petrella C., Ceccanti M., Fiore M. Nerve Growth Factor in the psychiatric brain. Rivista di Psichiatria. 2020 Jan-Feb;55(1):4-15. doi: 10.1708/3301.32713.

Messina MP., D’Angelo A., Battagliese G., Coriale G., Tarani L., Pichini S., Rasio D., Parlapiano G., Fiore M, Petrella C., Iannitelli A., Ferraguti G., Ceccanti M. Fetal Alcohol Spectrum Disorders Awareness in Health Professionals: Implications for Psychiatry. Rivista di Psichiatria. 2020; 55(2): 79-89. DOI 10.1708/3333.33022

Ralli M., Grasso M., Gilardi A., Ceccanti M., Messina MP., Tirassa P., Fiore M., Salzano FA., de Vincentiis M., Greco A. The role of cytokines in head and neck squamous cell carcinoma: A review. La Clinica Terapeutica 2020 May-Jun;171(3):e268-e274. doi: 10.7417/CT.2020.2225.

Coriale G., Gencarelli S., Battagliese G., Delfino D., Fiorentino D., Petrella C., Greco A., Ralli M., Attilia ML., Messina MP., Ferraguti G., Fiore M., Ceccanti M. Physiological Responses to Induced Stress in Individuals Affected by Alcohol Use Disorder with Dual Diagnosis and Alexithymia. La Clinica Terapeutica, 2020; 171(2):e120-e129. DOI:10.7417/CT.2020.2201

Coriale G., De Rosa F., Battagliese G., Porrari R., Gencarelli S., Fiore M., Carito V., Rotondo C., Attilia F., Attilia ML., Ceccanti M. Motivational enhancement therapy versus cognitive behavioral therapy in a cohort of men and women with alcohol use disorders. Biomedical Reviews. 2019; 30: 125-135. DOI: http://dx.doi.org/10.14748/bmr.v30.6393

Rosso P., Fiore M., Fico E., Iannitelli A., Tirassa P. Acute stimulation of vagus nerve modulates brain neurotrophins and stimulates neuronal plasticity in the hippocampus of adult male rats. Biomedical Reviews. 2019. 30: 99-109. DOI: http://dx.doi.org/10.14748/bmr.v30.6391

D’Angelo A., Ceccanti M., Petrella C., Greco A., Tirassa P., Rosso P., Ralli M., Ferraguti G., Fiore M, Messina MP. Role of Neurotrophins in Pregnancy, Delivery and Postpartum. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020 Jan 30;247:32-41. doi: 10.1016/j.ejogrb.2020.01.046

Petrella C., Carito V., Carere C., Ferraguti G., Ciafrè S., Natella F., Bello C., Greco A., Ralli M., Mancinelli R., Messina MP., Fiore M, Ceccanti M. Oxidative stress inhibition by Resveratrol in alcohol dependent mice. Nutrition 2020, 79-80. 110783.  https://doi.org/10.1016/j.nut.2020.110783

Ferraguti G., Codazzo C., Petrella C., Coccurello R., Ceccanti M., Fiore M. Brainstem Expression of SLC6A4, HTR2C, NGF, BDNF, TrkA, TrkB and p75 Following Paternal Alcohol Exposure in the Male Mouse. Biomedical Reviews 2020, 31, 75-89. DOI: http://dx.doi.org/10.14748/bmr.v31.7707.

Martellucci S., Ralli M., Attanasio G., Russo FY., Marcelli V., Greco A., Fiore M , Petrella C., Messina MP., Ferraguti G., Ceccanti M., de Vincentis M. Alcohol binge-drinking damage on the vestibulo-oculomotor reflex. European Archives of Oto-Rhino-Laryngology. 2021. 278, pages 41–48. https://doi.org/10.1007/s00405-020-06052-1

Tarani L., Carito V., Ferraguti G., Petrella C., Greco A., Ralli M., Messina MP., Rasio D., De Luca E., Putotto C., Ceccanti M., Fiore M . Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome. Journal of Immunology Research. 2020:6937154. doi: 10.1155/2020/6937154. eCollection 2020.

Rosso P., Iannitelli A., Pacitti F., Quartini A., Fico E., Fiore M., Greco A., Ralli M., Tirassa P. Vagus nerve stimulation and neurotrophins: A biological psychiatric perspective. Neuroscience & Biobehavioral Reviews. 2020. doi.org/10.1016/j.neubiorev.2020.03.034

Hiriart M., Fiore M., Chaldakov G. Save the obese man. Adipobiology. 2019. 10:197-111. DOI: http://dx.doi.org/10.14748/adipo.v10.6543

Fiore M, Messina MP., Petrella C., D’Angelo A., Greco A., Ralli M., Ferraguti G., Tarani L., Vitali M., Ceccanti M. Antioxidant Properties of Plant Polyphenols in the Counteraction of Alcohol-Abuse Induced Damage: Impact on the Mediterranean Diet. Journal of Functional Foods. 2020, 71, 104012. https://doi.org/10.1016/j.jff.2020.104012

Ciafrè S., Ferraguti G., Greco A., Polimeni A., Ralli M., Ceci FM., Ceccanti M., Fiore M. Alcohol an early life stressor: epigenetics, metabolic, neuroendocrine and neurobehavioral implications. Neuroscience & Biobehavioral Reviews 118 (2020) 654–668. https://doi.org/10.1016/j.neubiorev.2020.08.018

Ralli M., Botticelli A., Visconti IC., Fiore M., Marchetti M., Lambiase A., de Vincentiis M., Greco A., Angeletti D. Immunotherapy in the treatment of metastatic melanoma: current knowledge and future directions. Journal of Immunology Research, 2020, 9235638.  doi.org/10.1155/2020/9235638

Ceci FM., Ferraguti G., Petrella C., Greco A., Ralli M., Iannitelli A., Carito V., Tirassa P., Chaldakov GN., Messina MP., Ceccanti M., Fiore M. Nerve Growth Factor in Alcohol Use Disorders. Current Neuropharmacology, 2021, 19, 45-60. DOI: 10.2174/1570159X18666200429003239

Petrella C., Ferraguti G., Tarani L., Chaldakov GN., Ceccanti M., Greco A., Ralli M., Fiore M . Olive polyphenols and chronic alcohol protection. Chapter 39. In Olives and Olive Oil in Health and Disease Prevention 2^nd edition. Watson R.R., Preedy V.R. editors. 2021, pages 471-478. Academic Press doi.org/10.1016/B978-0-12-819528-4.00003-1

Ceci FM., Ferraguti G., Petrella C., Greco A., Tirassa P., Iannitelli A., Ralli M., Vitali M., Ceccanti M., Chaldakov GN., Fiore M. NGF, stress and diseases. Current Medicinal Chemistry. 2021, 28(15), pp. 2943–2959: doi: 10.2174/0929867327999200818111654.

Petrella C., Farioli-Vecchioli S., Cisale GY., Strimpakos G., Borg JJ., Ceccanti M., Fiore M, Monteleone G., Nisticò. A healthy gut for a healthy brain: preclinical, clinical and regulatory aspects. Current Neuropharmacology. 2021, 19(5), 610-628, DOI: 10.2174/1570159X18666200730111528

D’Angelo A., Ferraguti G., Petrella C., Greco A., Ralli M., Vitali M., Framarino dei Malatesta M., Fiore M, Ceccanti M., Messina MP. Challenges for Midwives’ Healthcare Practice in the Next Decade: COVID-19 – Global Climate Changes – Aging and Pregnancy – Gestational Alcohol Abuse. La Clinica Terapeutica 2021 Jan-Feb;171(1):e30-e36. doi: 10.7417/CT.2021.2277.

Pacitti F., Bersani G., Aloe L., Caredda M., Orsi P., Quartini A., Vitali M., Ceccanti M., Tirassa P., Fiore M., Iannitelli A. Nerve growth factor serum levels in treatment-resistant schizophrenic patients following electroconvulsive therapy. La Clinica Terapeutica 2021 Jan-Feb;171(1):e67-e74. doi: 10.7417/CT.2021.2286.

Iannitelli A., Tirassa P., Fiore M., Pacitti F., Quartini A., Rosso P., Fico E., Garavini A., Pompili F., Vitali M., Riccobono G. Bersani G. Gender differences in ultradian serum levels of NGF and BDNF correlate with psychophysical traits in healthy humans. Rivista di Psichiatria 2021; 56(6): 314-320. DOI 10.1708/3713.37045.

Ralli M., Angeletti D., Fiore M., D’Aguanno V., Lambiase A., Artico M., de Vincentiis M., Greco A. Hashimoto’s thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmunity Reviews 2020 Oct;19(10):102649. doi: 10.1016/j.autrev.2020.102649

D’Angelo A., Ceccanti M., Petrella C., Greco A., Porrari R., Gencarelli S., Ralli M., Vitali M., Ferraguti G., Galeoto G., Valente D., Framarino dei Malatesta M., Fiore M, Messina MP. Pregnancy in women with physical and intellectual disability: psychiatric implications. Rivista di Psichiatria 2020; Nov-Dec;55(6):331-336. doi: 10.1708/3503.34890.

Messina MP., Piccioni MG., Petrella C., Vitali M., Greco A., Ralli M., Ceccanti M., Ferraguti G., Neri I., Ricchi A., Fiore M, D’Angelo A. Advanced Midwifery Practice: Intrapartum Ultrasonography to Assess Fetal Head Station and Comparison with Vaginal Digital Examination. Minerva Obstetrics and Gynecology 2021 April;73(2):253-60. DOI: 10.23736/S2724-606X.21.04687-6

Messina MP., D’Angelo A., Giovagnoli R., Napolitano M., Petrella C., Ralli M., Greco A., Cavalcanti L., Ricchi A., Neri I., De Persis S., Fiore M, Ceccanti M. Cancer Screenings among Sexual and Gender Minorities by Midwives’ Point of View. Minerva Obstetrics and Gynecology. 2021. DOI: 10.23736/S2724-606X.21.04802-8

D’Angelo A., Petrella C., Greco A., Ralli M., Vitali M., Messina MP., Giovagnoli R., De Persis S., Fiore M., Ceccanti M. Acute Alcohol Intoxication: a Clinical Overview. La Clinica Terapeutica. 2022 May 25;173(3):280-291.doi: 10.7417/CT.2022.2432.

Tarani L., Rasio D., Tarani F., Parlapiano G., Valentini D., Dylag KA., Spalice A., Fiore M. Pediatrics of disability: a comprehensive approach to the child with syndromic psychomotor delay. Current Pediatric Reviews 2022;18(2):110-120. DOI: 10.2174/1573396317666211129093426.

Ceci FM., Ceccanti M., Petrella C., Vitali M., Messina MP., Chaldakiv GN., Greco A., Ralli M., Lucarelli M., Angeloni A., Fiore M , Ferraguti G. Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases. Current Neurovascular Research. 2021;18(1):150-161. doi: 10.2174/1567202618666210406123503.

Petrella C., Di Certo MG., Gabanella F., Barbato C., Ceci FM., Greco A., Ralli M., Polimeni A., Angeloni A., Severini C., Vitali M., Ferraguti G., Ceccanti M., Lucarelli M., Severi C., Fiore M . Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders. Current Medicinal Chemistry. 2021, 28(37), 7595-7616. DOI: 10.2174/0929867328666210504113445

Tarani L., Ceci F.M., Petrella C., Ferraguti G., Greco A., Ralli M., Putottu C., Versacci P., Fiore M. Neuroimmune Dysregulation in Prepubertal and Adolescent Individuals Affected by Klinefelter Syndrome. Endocr Metab Immune Disord Drug Targets. 2023, 23, 105-114. doi: 10.2174/1871530322666220704101310.

Fiore M, Petrella C, Coriale G., Rosso P., Fico E., Ralli M., Greco A., Polimeni A., Vitali M., Messina MP., Ferraguti G., Paparella R., Tarani F., Ceccanti M., Tarani L. Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders. CNS & Neurological Disorders – Drug Targets 2022;21(9):854-868. doi: 10.2174/1871527320666211201154839

Ceci FM., Fiore M, Agostinelli E., Tahara T., Greco A. Ralli M., Polimeni A., Coletti R., Lucarelli M., Angeloni A., Tirassa P., Ceccanti M., Messina M.P., Vitali M., Petrella C., Ferraguti G. Urinary Ethyl Glucuronide for the Assessment of Alcohol Consumption During Pregnancy: Comparison between Biochemical Data and Screening Questionnaires. Current Medicinal Chemistry, 2022, 29, 3125-3141. DOI: 10.2174/0929867328666211125100329

Meschino N., Laviola G., Busdraghi LM., Petrella C., Fiore M. Aberrant Early in Life Stimulation of the Stress-Response System Affects Emotional Contagion and Oxytocin Regulation in Adult Male Mice. International Journal of Molecular Sciences 2021, 22, 5039. https://doi.org/10.3390/ijms22095039

Messina MR., D’Angelo A., Battaglese G., Pisciotta F., Tramonte L., Fiore M., Ferraguti G., Ceccanti M. Knowledge and Practice towards Alcohol Assumption in a Sample of University Students. International Journal of Environmental Research and Public Health. 2021, 18, 9528. doi.org/10.3390/ ijerph18189528

D’Angelo A., Giacomin L., Murabito L., Ciceroni V., Petrella C., Fiore M, Ceccanti M., Messina MP. Caesarean Section in Preventing Stillbirths in Pregnancy Complicated with COVID-19: a Narrative Review. La Clinica Terapeutica. 2021 Nov 22;172(6):570-576. doi: 10.7417/CT.2021.2380.

Chaldakov GN., Aloe L., Ghenev P., Fiore M., Pancheva RZ., Panayotov P. Tribute to Geroge E. Palade. Cell protein secretion: overview and updates. Acta Biologica Marisiensis 2021, 4(1) 31-43. DOI: 10.2478/abmj-2021-0004

Ralli M., Angeletti D., D’Aguanno V., Campo F., Fiore M., Greco A., de Vincentiis M. Evaluation of Surgical and Functional Outcomes of Supracricoid Laryngectomy and Rehabilitation Protocol. Clinica Terapeutica. 2021 Jul 5;172(4):363-368. doi: 10.7417/CT.2021.2341.

Chaldakov GN, Zhelyazkova-Savova MD, Panayotova D, Fiore M, Yanev S. Phenotypic modulation of smooth cells and matrix metalloproteinase as targets for atherosclerotic plaque stabilization. Biomedical Reviews 2020; 31: 49-60. http://dx.doi.org/10.14748/bmr.v31.7704

Barbato C., Di Certo MG, Gabanella F, Petrella C, Fiore M, Passananti C, Colizza A, Cavalcanti L, Ralli M, Greco A, de Vincentiis M, Minni A. Staying tuned for Post-Covid-19 syndrome: looking for new research to sniff out. European Review for Medical and Pharmacological Sciences. 2021; 25 (16): 5310-5317. DOI: 10.26355/eurrev_202108_26552

Fiore M, Tarani L, Radicioni A, Spaziani M, Ferraguti G, Putotto C, Gabanella F, Maftei D, Lattanzi R, Minni A, Tarani F, Petrella C. Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals. Can. J. Physiol. Pharmacol. 100: 151–157 (2022) dx.doi.org/10.1139/cjpp-2021-0457

Gabanella F, Barbato C, Fiore M, Petrella C, de Vincentiis M, Greco A, Minni A, Corbi N, Passananti C, Di Certo MG. Fine-tuning of mTOR mRNA and nucleolin complexes by SMN. Cells 2021,10,3015. https://doi.org/ 10.3390/cells10113015

Tarani L, Fiore M, Pichini S, Coriale G, Ceccanti M. La sindrome feto-alcolica: diagnosi, trattamento e prevenzione. Pediatria Preventiva e Sociale. ANNO XVI – Numero 3 – 2021 pp 36-42. ISSN 1970-8165

Chaldakov GN, Aloe L, Rancic G, Pancheva RZ, Hiriart M, Fiore M, Yanev S. The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases. Chapter 16. pp.297-312. In P. S. Tappia et al. (eds.), Cellular and Biochemical Mechanisms of Obesity. Advances in Biochemistry in Health and Disease. Springer Nature Switzerland AG 2021. https://doi.org/10.1007/978-3-030-84763-0_16

Ceci FM, Francati S, Ferraguti G, Coriale G, Ciccarelli R, Minni A, Greco A, Musacchio A, De Persis S, Vitali M, Tarani L, Ceccanti M, Messina MP, Fico E, Rosso P, Fiore M. Behavioral Dysregulations by Chronic Alcohol Abuse. Motivational Enhancement Therapy and Cognitive Behavioral Therapy Outcomes. Rivista di Psichiatria. 2022 Jan-Feb;57(1):1-9. doi: 10.1708/3749.37321.

Ferraguti G, Terracina S, Petrella C, Greco A, Minni A, Lucarelli M, Agostinelli E, Ralli M, de Vincentiis M, Raponi G, Polimeni A, Ceccanti M, Caronti B, Di Certo MG, Barbato C, Mattia A, Fiore M. Alcohol-induced oxidative stress in head and neck cancer. Updates on the role of genetic, epigenetics, oral microbiota, antioxidants, and alkylating agents. Antioxidants. 2022, 11,145. https://doi.org/10.3390/ antiox11010145

Fiore M. Meet the Editorial Board Member. 2021, Current Neuropharmacology, 2021, Vol. 19, No. 12 2057. DOI : 10.2174/1570159X1912211213141725. PMCID: PMC9185758

Ceci FM, Fiore M, Gavaruzzi, F, Angeloni A, Lucarelli M, Scagnolari C, Bonci E, Gabanella F, Di Certo MG, Barbato C, Petrella C, Greco A, De Vincentiis M, Ralli M, Passananti C, Poscia R, Minni A, Ceccanti M, Tarani L, Ferraguti G. Early routine biomarkers of SARS-CoV-2 morbidity and mortality. Outcomes from an emergency section. Diagnostics. 2022, 12, 176. DOI: 10.3390/ diagnostics12010176

Mattia A., Moschella C., David MC., Fiore M., Gariglio S., Salomone A. Vincenti M. Development and validation of an innovative GC-EI-MS/MS method for ethyl glucuronide quantification in human hair. Frontiers in Chemistry. Front. Chem. 10:858205. doi: 10.3389/fchem.2022.858205

Di Certo MG, Gabanella F, Barbato C, Corbi N, Fiore M, Petrella C, De Vincentiis M, Greco A, Ferraguti G, Corsi A, Ralli M, Pecorella I, Di Gioia CRT, Pecorini F, Brunell R, Passananti C, Minni A. Exploring mitochondrial localization of SARS-CoV-2 RNA by Padlock Assay. A pilot study in human placenta. International Journal of Molecular Sciences. 2022, 23, 2100. https://doi.org/10.3390/ijms23042100

Petrella C., Nenna R., Petrarca L., Tarani F., Paparella R., Mancino E., Di Mattia G., Conti MG., Matera L., Bonci E., Ceci FM., Ferraguti G., Gabanella F., Barbato C., Di Certo MG., Cavalcanti L., Minni A., Midulla F., Tarani L., Fiore M. Serum NGF and BDNF in Long-COVID-19 Adolescents. A Pilot Study. Diagnostics 2022, 12, 1162. https://doi.org/10.3390/ diagnostics12051162.

Terracina S., Ferraguti G., Petrella C., Bruno SM., Blaconà G., Di Certo MG., Minni A., Greco A., Musacchio A., Ralli M., Tarani L., Ceccanti M., Polimeni A., Triaca V., Fiore M. Characteristic Hallmarks of Aging and the Impact on Carcinogenesis. Curr Cancer Drug Targets. 2023;23(2):87-102. doi: 10.2174/1568009622666220816120353. Online ahead of print.

Ragno R, Minarini A, Proia E, Milelli LA, Tumiatti V, Fiore M, Fino P, Rutigliano L, Fioravanti R, Tahara T, Pacella E, Greco A, Canettieri G, Di Paolo ML. Agostinelli E, Bovine Serum Amine Oxidase and polyamine analogues: chemical synthesis and biological evaluation integrated with molecular docking and 3-D QSAR studies. J Chem Inf Model. 2022 Aug 22;62(16):3910-3927. doi: 10.1021/acs.jcim.2c00559.

De Luca P, Ralli M, Cassandro C, Yoshie Russo F, Gioacchini FM, Cavaliere M, Fiore M, Greco A. Surgical Management of Intractable Meniere’s Disease. International Tinnitus Journal. 2022;26(1):50-56. DOI: 10.5935/0946-5448.20220007

Micangeli G, Profeta G, Colloridi F, Pirro F, Tarani F, Ferraguti G, Spaziani M, Isidori AM, Menghi M, Fiore M, Tarani L. The Role of the Pediatrician in the Management of the Child and Adolescent with Gender Dysphoria. Italian Journal of Pediatrics. Pediatrics (2023) 49:71. https://doi.org/10.1186/s13052-023-01466-z

Ceci FM, Fiore M, Ceccanti M, Ferraguti G. Disclosing alcohol abuse during gestation by urine ethyl glucuronide. Biomedical Reviews 2021; 32: 61–70.  DOI: http://dx.doi.org/10.14748/bmr.v32.8504

Profeta G, Micangeli G, Tarani F, Paparella R., Ferraguti G, Spaziani M, Isidori AM, Menghi M, Ceccanti M., Fiore M, Tarani L. Sexual Developmental Disorders in Pediatrics. La Clinica Terapeutica. 2022 Sep-Oct;173(5):475-488. doi: 10.7417/CT.2022.2466.

Fanfarillo F, Ferraguti G., Francato S, Barbato C, Minni A, Ceccanti M, Tarani L, Petrella C, Fiore M. The Impact of ROS and NGF in the Gliomagenesis and their Emerging Implications in the Glioma Treatment. CNS and Neurological Disorders – Drug Targets. 23, Number 4, 2024, pp. 449-462(14). doi: 10.2174/1871527322666230403105438.

Ceci FM, Ferraguti G, Lucarelli M, Angeloni A, Bonci E, Petrella C, Francati S, Barbato C, Di Certo MG, Gabanella F, Gavaruzzi F, Mastroianni CM, Minni A, Greco A, Ralli M, Ceccanti M, Tarani L, Fiore M.  Investigating Biomarkers for COVID-19 Morbidity and Mortality. Current Topics Medicinal Chemistry. 2023;23(13):1196-1210. doi: 10.2174/1568026623666230222094517

Chaldakov GN, Aloe L, Ozturk L, Pancheva RZ, Fiore M, Yanev S, Tonchev AB. Adipokines and Myokines (Adipomyokines) in Diabetes and Related Cardiometabolic Diseases: An (Un)expected Alliance. In Advance in Diabetes, Waterstones

Zoccali F, Cambria F, Colizza A, Ralli M, Greco A, de Vincentiis M, Petrella C, Fiore M, Minni A, Barbato C. Sudden sensorineural hearing loss after third dose booster of COVID-19 vaccine administration. Diagnostics 2022, 12(9), 2039; https://doi.org/10.3390/diagnostics12092039

Aloe L., Vinciguerra M., Tonchev AB., Fiore M., Deleva N., Frohlich J., Chaldakov GN. A Growing Journey From Neurotrophins To Metabotrophins In Cardiometabolic Diseases. Adipobiology 2021; 11: 5-10. DOI: http://dx.doi.org/10.14748/adipo.v11.8558

Chaldakov GN., Aloe L., Vinciguerra M., Tonchev AB., Fiore M., Ozturk L. The Adipose Mast Cell: Mastokines As Binary Modulators Of Disease Processes. Adipobiology 2021; 11: 27-34. DOI: http://dx.doi.org/10.14748/adipo.v11.8560

Riccardi G, Bellizzi MG, Fatuzzo I, Zoccali I, Cavalcanti L, Greco A, de Vincentiis M, Ralli M., Fiore M, Petrella C, Minni A, Barbato C. Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview. Proteomes, 2022 10(4), 37. https://doi.org/10.3390/proteomes10040037.

Petrella C, Spaziani M, d’Orazi V, Tarani L, Terracina S, Tarani F, Micangeli G, Barbato C, Minni A, Greco A, Isidori AM, Ferraguti G, Fiore M . Prokineticin 2/PROK2 and male infertility. Biomedicines 2022 Sep 25;10(10):2389. doi: 10.3390/biomedicines10102389.

Micangeli G, Menghi M, Profeta G, Tarani F, Mariani A, Petrella C, Barbato C, Ferraguti G, Ceccanti M, Tarani L, Fiore M. The Impact of Oxidative Stress on Pediatrics Syndromes. Antioxidants. 2022 Oct 5;11(10):1983. doi: 10.3390/antiox11101983.

De Nardo MC, Petrella C, Di Chiara M, Di Mario C, Deli G, Baldini L, Travaglia E, Russo A, Parisi P, Fiore M (co last name), Terrin G. Early nutritional intake influences the serum levels of NGF and BDNF in preterm newborns. Frontiers in Neurology. 2022 DOI 10.3389/fneur.2022.988101

Ferraguti G, Fanfarillo F, Tarani L, Blaconà G, Tarani F, Barbato C, Minni A, Ralli M, Francati S, Greco A, Petrella C, Fiore M. NGF and the Male Reproductive System: Potential Clinical Applications in Infertility. International Journal in Molecular Sciences. 2022, 23, 13127. https://doi.org/10.3390/ ijms232113127

Terracina S, Petrella C, Francati S, Lucarelli M, Barbato C, Minni A, Ralli M, Greco A, Tarani L, Fiore M, Ferraguti G. Antioxidant intervention to improve cognition in the aging brain. The example of hydroxytyrosol and resveratrol. International hournal of Molecular Sciences. 2022, 23, 15674. https://doi.org/10.3390/ ijms232415674

Terracina S, Pallaria A, Lucarelli M, Angeloni A, De Angelis A, Petrella C, Caronti B, Francati S, Blacona G, Fiore M, Ferraguti G. Urine Dipstick Analysis on Automated Platforms: Is a Reliable Screening Tool for Proteinuria? An Experience from Umberto I Hospital in Rome. Biomedicines 2023, 11, 1174. https://doi.org/10.3390/biomedicines11041174

Meliante PG, Barbato C, Zoccali F, Ralli M, Greco A, de Vincentiis M, Colizza A, Petrella C, Ferraguti G, Minni A, Fiore M. Programmed Cell Death-Ligand 1 in Head and Neck Squamous Cell Carcinoma: Molecular Insights, Preclinical and Clinical Data, and Therapies. International Journal in Molecular Sciences. 2022, 23, 15384. https://doi.org/10.3390/ ijms232315384

Gabanella G, Colizza A, Mottola MC, Francati S, Blaconà G, Petrella C, Barbato C, Greco A, Ralli M, Fiore M, Corbi N, Ferraguti G, Corsi A, Minni A, de Vincentiis M, Passananti C, Di Certo MG. The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma. Int. J. Mol. Sci. 2023, 24,1794. https://doi.org/10.3390/ ijms24021794

Fatuzzo I, Niccolini GF, Zoccali F, Cavalcanti L, Bellizzi MG, Riccardi G, De Vincentiis M, Fiore M, Petrella C, Minni A, Barbato C. Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment.    International Journal of Molecular Sciences 24(3):2117. DOI: 10.3390/ijms24032117

Gabanella F, Onori A, Pisani C, Fiore M, Ferraguti G, Colizza A, De Vincentiis M, Ceccanti M, Inghilleri M, Corbi N, Passananti C, Di Certo MG. SMN Deficiency Destabilizes ABCA1 Expression in Human Fibroblasts. Novel Insights in Pathophysiology of Spinal Muscular Atrophy. International Journal of Molecular Sciences 2023, 24, 2916. https://doi.org/10.3390/ijms24032916

Meliante PG, Zoccali F, De Vincentiis M, Ralli M, Fiore M, Minni A, Barbato C. Diagnostic predictors of immunotherapy response in head and neck squamous cell carcinoma. Diagnostics 2023, 13(5), 862; https://doi.org/10.3390/diagnostics13050862

Petrella C, Zingaropoli MA, Ceci FM, Pasculli P, Latronico T, Liuzzi GM, Ciardi MR, Angeloni A, Ettorre E, Menghi M, Barbato C, Ferraguti G, Minni A, Fiore M. COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality. Cells 2023, 12, 655. https://doi.org/10.3390/cells12040655

Menghi M, MIcangeli G, Tarani F, Putotto C, Pirro F, Mariani A, Petrella C, Pulvirenti F, Cinicola B, Colloridi F, Tarani L, Fiore M . Neuroinflammation and oxidative stress in individuals affected by DiGeorge syndrome. Int. J. Mol. Sci. 2023, 24, 4242. https://doi.org/10.3390/ijms24044242

Fatuzzo I, Colizza A, Meliante PG, Altomari R, Elfarargy H, Fiore M, Ralli M, Messineo D, Greco A, De Vincentiis, M, Barbato C, Minni A. The Impact of the COVID-19 Pandemic on the Prognosis of the Laryngeal Adenoid-Cystic Carcinoma: a case report and literature review. Diagnostics. 2023, 13, 905. https://doi.org/10.3390/diagnostics13050905

Meliante PG, Zoccali F, Cascone F, Di Stefano V, Greco A, de Vincentiis M, Petrella C, Fiore M, Minni A, Barbato C. Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea. Int J Mol Sci. 2023 Mar 13;24(6):5478. doi: 10.3390/ijms24065478.

Paparella R, Menghi M, Micangeli G, Leonardi L, Profeta G, Tarani F, Petrella C, Ferraguti G, Fiore M, Tarani L. Autoimmune Polyendocrine Syndromes in the Pediatric Age. Children (Basel). 2023 Mar 19;10(3):588. doi: 10.3390/children10030588.

Pennacchia F, Rusi E, Abu Ruqa W, Zingaropoli MA, Pasculli P, Talarico G, Bruno G, Barbato C, Minni A, Tarani L, Galardo G, Pugliese F, Lucarelli M, Ferraguti G, Ciardi MR, Fiore M. Blood Biomarkers from an Emergency Section Disclose Severe Omicron COVID-19 Outcomes. Microorganisms 2023, 11(4), 925; https://doi.org/10.3390/microorganisms11040925

Zoccali F, Petrella C, Zingaropoli MA, Fiore M, Ralli M, Minni A, Barbato C. Neurofilament Expression as a Biomarker of Post-COVID-19 Sudden Sensorineural Hearing Loss. Diseases. 2023 Jun 29;11(3):92. doi: 10.3390/diseases11030092.

Spaziani M, Carlomagno F, Tenuta M, Sesti F, Angelini F, Bonaventura I, Ferrari D, Tarantino C Fiore M, Petrella C, Tarani L, Gianfrilli D, Pozza C. Extra-gonadal and non-canonical effects of FSH in males. Pharmaceuticals 2023, 16, 813. https://doi.org/10.3390/ph16060813

Aloe L, Tonchev AB, Hiriart M, Fiore M, Vinciguerra M, Hristova M, Rancic G, Maucher A, Yanev S, Moreno W, Edzhabi G, Chaldakov GN. Concept of metabotrophin: beginning and prospective growth. Biomedical Reviews 2022; 33: 33-41. DOI: http://dx.doi.org/10.14748/bmr.v33.9117.

Riccardi G, Niccolini GF, Bellizzi MG, Fiore M, Minni A, Barbato C. Post-Covid-19 Anosmia and Therapies: Stay tuned for new drugs to sniff out. Diseases 2023, 11, 79. https://doi.org/10.3390/ diseases11020079

Fiore M, Minni A, Cavalcanti L, Raponi G, Puggioni G, Mattia A, Gariglio S, Colizza A, Meliante PG, Zoccali F, Tarani L, Barbato C, Lucarelli M, Ceci FM, Francati S, Ferraguti G, Ceccanti M, Petrella C. The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study. Antioxidants 2023, 12, 1233. https://doi.org/10.3390/antiox12061233

Mastino P, Rosati D, De Soccio G, Romeo M, Pentangelo D, Minni A, Venarubea S, Fiore M, Meliante PG, Petrella C, Barbato C. Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to the hearing system impairment. Antioxidants 2023, 12(7), 1430; https://doi.org/10.3390/antiox12071430

Derme M. Piccioni MG, Brunelli R, Crognale A, Denotti M, Ciolli P, Scomparin D, Tarani L, Paparella R, Terrin G, Di Chiara M, Matia A, Nicotera S, salomone A, Ceccanti M, Messina MP, La Maida N, Ferraguti G, Petrella C, Fiore M. Oxidative Stress in a Mother Consuming Alcohol during
Pregnancy and in Her Newborn: A Case Report. Antioxidants 2023, 12, 1216. https://doi.org/10.3390/antiox12061216

Yanev S, Aloe L, Panayotova D, Vinciguerra M, Evtimov NT, Tonchev AB, Fiore M, Ghenev PI, Chaldakov GN. Theragnostics of TRK-targeting agents (trackins): a challenge that promises reward. Biomedical Reviews 2022; 33: 53-60. DOI: http://dx.doi.org/10.14748/bmr.v33.9120.

Peracchini M, Agostini A, D’Angelo A, Sicignano T, Santoni G, Finale E, Ceccanti M, Napolitano M, Fiore M, Tarani L, Dylag KA, Messina MP. The psychological support for women who underwent a stillbirth during their pregnancy: the quality of midwifery care. Riv Psichiatr. 2023 Jul-Aug;58(4):143-153. doi: 10.1708/4064.40476.

Meliante P.G., Petrella C, Fiore M, Minni A, Barbato C. Antioxidant Use after Diagnosis of Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review of Application during Radiotherapy and in Second Primary Cancer Prevention. Antioxidants 2023, 12, 1753. https://doi.org/10.3390/antiox12091753

Zingaropoli MA, Pasculli P, Barbato C, Petrella C, Fiore M, Dominelli F, Latronico T, Ciccone F, Antonacci M, Liuzzi GM, Talarico G, Bruno G, Galardo G, Pugliese F, Lichtner M, Mastroianni CM, Minni A, Ciardi MR. Biomarkers of Neurological Damage: From Acute Stage to Post-Acute Sequelae of COVID-19. Cells 2023, 12(18), 2270; https://doi.org/10.3390/cells12182270

Fanfarillo F, Ferraguti G, Lucarelli M, Fuso A, Ceccanti M, Terracina S, Micangeli G, Tarani L, Fiore M. The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol Use Disorders. Current Medicinal Chemistry 2023 Oct 11. doi: 10.2174/0109298673256937231004093143.

Micangeli G, Paparella F, Trani F, Menghi M, Ferraguti G, Carlomagno F, Spaziani M, Pucarelli I, Greco A, Fiore M, Tarani L. Clinical Management and Therapy of Precocious Puberty in the Sapienza University Pediatrics Hospital of Rome, Italy. Children 2023, 10, 1672. https://doi.org/10.3390/ children10101672

Micangeli G, Menghi M, Profeta G, Paparella R, Tarani F, Petrella C, Barbato C, Minni A, Greco A, Ferraguti G, Tarani L, Fiore M. Malignant and Benign Head and Neck Tumors of the Pediatric Age. A Narrative Review. Current Pediatric Reviews. 2025, 21, 118 – 132.  DOI:10.2174/0115733963258575231123043807

Nenna R, Petrella C, Papoff P, di Jorgi M, Petrarca L, Conti MG, Barbato C, Pietrangeni A, BROME Group, Fiore M, Midulla F. Reduced Serum Brain-Derived Neurotrophic Factor in Infants Affected by Severe Bronchiolitis. Current Neuropharmacology 2024, 22(14), 2433-2442. DOI: 10.2174/1570159X22999240223153901

Terracina S, Ferraguti G, Tarani L, Fanfarillo F, Tirassa P, Ralli M, Iannella G, Polimeni A, Lucarelli M, Greco A, Fiore M. NGF and Autoimmune Diseases. Current Issue in Molecular Biology. 2023, 45, 8950–8973. https://doi.org/ 10.3390/cimb45110562

Meliante PG, Petrella C, Fiore M, Minni A, Barbato C. Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives. Curr. Issues Mol. Biol. 2023, 45, 9215–9233. https://doi.org/10.3390/ cimb45110577

Coriale G, Ceccanti M, Fiore M, Tarani F, Ginevra Micangeli, Michela Menghi, Minutillo A, Berretta P, Ferraguti G, Iannitelli A, Parlapiano G, Paparella R. Messina MP, Vitali M, Pichini S, Tarani L. Delay in the Fine-Tuning of Locomotion in Infants with Meconium Positive to Biomarkers of Alcohol Exposure: A Pilot Study. Rivista di psichiatria 2024; 59: 52-59

D’Angelo A, Peracchini M, Agostini A, Di Matteo C, Fiore M, Ceccanti M, Vitali M, Messina MP. The Impact of Oxidative Stress on pregnancy. The Neglected Role of Alcohol Misuse. La Clinica Terapeutica. 2024 Jan-Feb;175(1):47-56. doi: 10.7417/CT.2024.5033.

Ferraguti S, Terracina S, Tarani L, Fanfarillo F, Allushi S, Caronti B, Tirassa, Polimeni A, Lucarelli M, Cavalcanti L, Greco A, Fiore M. Nerve Growth Factor and the Role of Inflammation in Tumor Development. Current Issue in Molecular Biology. 2024, 46, 965–989. https://doi.org/10.3390/ cimb46020062

Paparella R, Ferraguti G, Fiore M, Menghi M, Micangeli M, Tarani L, Ligotino A, Messina Marisa Patrizia, Ceccanti M, Minni A, Barbato C, Lucarelli M, Tarani L, Petrella C. Serum Lipocalin-2 Levels as a Biomarker in Pre- and Post-Pubertal Klinefelter Syndrome Patients: A Pilot Study. International Journal of Molecular Sciences 2024,25,2214. https:// doi.org/10.3390/ijms25042214

Francati S, Fiore M, Ferraguti G. The Janus face of oxidative stress in health and disease: the cause or the cure? Biomedical Reviews 2023; 34: 13-26. DOI: 10.14748/bmr.v34.9606

Panvino F, Paparella R, Gambuti L, Cerrito A, Menghi M, Micangeli G, Petrella C, Fiore M, Tarani L, Ardizzione I. Klinefelter Syndrome: A Genetic Disorder Leading to Neuroendocrine Modifications and Psychopathological Vulnerabilities in Children – A Literature Review and Case Report. Children 2024, 11,509. https://doi.org/10.3390/children11050509

Terracina S, Tarani L, Ceccanti M, Vitali M, Francati S, Lucarelli S, Venditti S, Verdone L, Ferraguti G, Fiore M. The Impact of Oxidative Stress on the Epigenetics of Fetal Alcohol 
Spectrum Disorders. Antioxidants 2024, 13(4), 410; https://doi.org/10.3390/antiox13040410

Chaldakov GN, Zhelyazkova-Savova MD, Panayotova D, Tonchev AB, Vinciguerra M, Yanev SG, Fiore M, Ghenev P. Colchicine and therapy of cardiovascular disease: Not merely a theory. Biomedical Reviews 2023; 34: 181-184. http://dx.doi.org/10.14748/bmr.v34.9625

Atanassova P, Tonchev AB, Peneva VN, Chaldakov GN, Valchanov KP, Fiore M, Aloe L. Viewpoint 3. Experimental Dermatology 2007. 16, 56-59. https://doi.org/10.1111/j.1600-0625.2006.00519_5.x

Rusi E, Pennacchia F, Ruqa WA, Zingaropoli MA, Pasculli P, Talarico G, Bruno G, Barbato C, Minni A, Tarani L, Galardo G, Pugliese F, Lucarelli M, Ciardi MR, Meucci L, Ferraguti G, Fiore M. Blood Count and Renal Functionality Assessments in the Emergency Section Disclose Morbidity and Mortality in Omicron COVID-19 Patients: A Retrospective Study. Clinics and Practice 2024, 14, 685–702. https://doi.org/10.3390/clinpract14030055

Micangeli G, Menghi M, Paparella R, Ceccanti M, Coriale G, Fiorentino D, Ferraguti G, Fiore M, Tarani L. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Diagnostic Criteria. Rivista di Psichiatria Riv Psichiatr 2024;59(5):195-202 | DOI 10.1708/4360.43509

Menghi M, Micangeli G, Paparella R, Ceccanti M, Coriale G, Ferraguti G, Fiore M, Fiorentino D, Tarani L. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Clinical Hallmarks. Rivista di Psichiatria. 2024;59(5):203-211 | DOI 10.1708/4360.43510

Micangeli G, Paparella R, Menghi M, Ceccanti M, Coriale G, Fiorentino D, Hoyme EH, Fiore M, Ferraguti G, Corsello G, Pichini S, Tarani L. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: International Diagnostic Criteria – Differences and Similarities. Rivista di Psichiatria Riv Psichiatr 2024;59(5):212-220 | DOI 10.1708/4360.43511

Terracina S, Ferraguti G, Fanfarillo F, Coriale G, Ceccanti M, Fiorentino D, Tarani L, Fiore M. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Structural Abnormalities. Rivista di Psichiatria. 2024;59(5):221-229 | DOI 10.1708/4360.43512

Coriale G, Barzacchi A, Fiorentino D, Tarani L, Messina MP, Scamporrito MC, Ducci G, Cavallari S, Fiore M, Ceccanti M. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Multimodal Approaches of Treatment and Intervention. Rivista di Psichiatria. 2024;59(5):230-240 | DOI 10.1708/4360.43513

Ferraguti G, Fanfarillo F, Nicotera S, Terracina S, Moschella C, Mattia A, David, MC, Pichini S, Coriale G, Fiorentino D, Ceccanti M, Tarani L, Fiore M. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Detecting Alcohol Drinking during Pregnancy. Rivista di Psichiatria. 2024;59(5):241-249 | DOI 10.1708/4360.43514

Fiorentino D, Coriale G, Tarani L, Fiore M, Vitali M, Messina MP, Ceccanti M. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Prevention and Health Promotion. Rivista di Psichiatria. 2024;59(5):250-258 | DOI 10.1708/4360.43515

Ceccanti M, Coriale G, Fiorentino D, Tarani L, Messina MP, Vitali M, Fiore M, May PA. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Epidemiology. Rivista di Psichiatria. 2024;59(5):259-268 | DOI 10.1708/4360.43516

Coriale G, Barzacchi A, Ceccanti M, Tarani L, Gencarelli S, Elmo MG, Mistretta M, Messina MP, De Persis S, Fiore M, Fiorentino D. Italian Guidelines for the Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: Cognitive and Behavioral Deficits. Rivista di Psichiatria. 2024;59(5):269-277 | DOI 10.1708/4360.43517

Chaldakov GN, Aloe L, Yanev SG, Fiore M, Tonchev AB, Vinciguerra M, Evtimov NT, Ghenev P, Dikranian K. Trackins (Trk-Targeting Drugs): a Novel Therapy for Different Diseases. Pharmaceuticals Pharmaceuticals 2024, 17(7), 961; https://doi.org/10.3390/ph17070961

Ferraguti G, Francati S, Codazzo C, Blaconà G, Testino G, Angeloni A, Fiore M, Ceccanti M, Lucarelli M. DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction? International Journal of Molecular Sciences, 2024, 25(15), 8089. DOI. 10.3390/ijms25158089

Di Dio C, Pipitone S, Del Vecchio R, Noce E, Ceccanti M, Tarani L, Muzii L, Ferraguti G, Fiore M, Piccioni MG. Decoding Uterine Leiomyosarcoma: Is Ultrasound Diagnosis Still a Daunting Challenge. Diagnostics in press

Fiore M, Cambieri C, Libonati L, Moret F, D’Andrea E, Di Certo MG, Passananti C, Gabanella F, Corbi N, Garibaldi M, Chimenti C, Alfarano M, Ferraguti G, Francati S, Inghilleri M, Ceccanti M. Oxidative stress in transthyretin-mediated amyloidosis: an exploratory study. Antioxidants. 2024,13,998. https://doi.org/ 10.3390/antiox13080998

Leonardi L, Perna C, Bernabei I, Fiore M, Ma M, Frankovich J, Tarani L, Spalice A. Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Immunological Features Underpinning a Controversial Entity. Children 2024, 11(9), 1043; https://doi.org/10.3390/children11091043

Di Chiara M, Terrin G, Fiore M, De Nardo MC, Laccetta G, Gloria F, Minni A, Barbato C, Petrella C. Early Enteral Feeding Restores Neurofilament Light Chain Serum Levels in Preterm Newborns. Current Neuropharmacology, 2024 Nov 7. doi: 10.2174/1570159X23666240920165612. Online ahead of print.

Petrella C, Ferraguti G, Tarani L, Tarani F, Messina MP, Fiore M. Nerve Growth Factor and Brain-Derived Neurotrophic Factor in COVID-19. Biology 2024, 13, 907. https://doi.org/10.3390/biology13110907

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