Molecular oncology and genome instability

Group Leader : Manuela PellegriniTopic: Molecular oncology and pathologyKey words: Genomic/Genetic instability; ATM Gene therapy; Animal models;   Genomic instability is a key event of cancer. To preserve genomic stability cells have developped systems to detect and repair DNA double strand breaks (DSBs).DSBs occur in response to exogenous agents, such as chemoterpeutics and during physiological processes…

Read More

Molecular Neuro-Oncology

Group Leader : Maria Laura FalchettiTopic: Molecular oncology and pathology   The research focus of our lab is the brain tumor glioblastoma (GBM). Our research has evolved over time, but the characterizing red trail has always been GBM. We studied different aspects, some dealing with GBM tumor biology, others are therapy-oriented. GBM is the most…

Read More

Neurobiology and Neuromolecular Medicine

Group Leader : Christian BarbatoKeywords : neurodegenerative disease; microRNAs; RNA-Binding ProteinsTopic : Neurobiology Study of the role of RNA-induced Silencing Complex (RISC), small non-coding RNA and RNA-binding proteins in nervous system. Biomarkers in neurological and cancer disease; Key Pubblications 1) Canu N, Dus L, Barbato C, Ciotti MT, Brancolini C, Rinaldi A, Novak M, Cattaneo A, Bradbury A…

Read More

membrane trafficking, RNA metabolism, Duchenne Muscular Dystrophy 

Group leader : Maria Grazia Di CertoKeywords : membrane trafficking, RNA metabolism, Duchenne Muscular Dystrophy Topics : Neurobiology, Muscle physiology and pathology Our main research interest is to understand how RNA-related proteins impact cellular/tissue homeostasis in health and disease.Ongoing studies aim to assess the intriguing interplay between RNA metabolism and membrane trafficking regulating gene expression at subcellular…

Read More

muscle biopathology, noncoding RNAs, gene therapy

Group Leader: Germana FalconeTopics : Muscle Biology and PathologyKeywords: muscle biopathology, nocoding RNAs, gene therapy Our research group has a wide long-standing experience in molecular and cellular biology of muscle cells, intracellular cell signaling in oncogenic transformation and differentiation, and post-transcriptional regulation of gene expression, particularly microRNA analysis and studies on microRNA-target interaction. In past…

Read More

Neurodegeneration, Neuroinflammation and Pain 

Group Leader : Sara MarinelliKey words: autophagy, myelin, glia, disease-related biomarkers, immune cellsTopics : Neurobiology Our research group is involved in three main fields of study: A) Peripheral Neuropathies and Inflammatory Pain Nutrition, metabolic disorders, aging and gender-differences in incidence of neuropathic pain development: spinal and peripheral nerve mechanisms of inflammation and degeneration. New therapeutic…

Read More

Motor Functions, Pain, Botulinum neurotoxins

Group Leader : Siro LuvisettoTopics: Neurobiology Exercise is a common and necessary component of rehabilitative therapy for functional recovery after traumatic injuries of peripheral nervous system. The onset of neuropathic pain is often a consequence of such traumatic events. A first aim of my research is to assess what protocol of treadmill exercise is effective…

Read More

EMOTIONALITY, DEVELOPMENTAL PSYCHOBIOLOGY, mu-OPIOID SYSTEM

Group Leader : Francesca R. D’amatoTopic: Neurobiology   The main object of my research is the evaluation of gene X environment interaction on behavioural phenotypes in the mouse.In particular I’m interested in the evaluation of emotional and social behaviors during development and at adulthood in mouse models of developmental psychopathologies. Mother-infant interaction and the effect…

Read More

Mucosal Immunology and Immune Nutrition (MIIN LAB)

Group Leader: Carmen GianfraniTopics: Immunity and Infection   MIIN LAB, is a mucosal immunologist interested in studying the interaction between food proteins and gastrointestinal immune system. Her research is mainly focused on the disregulation of immune tolerance to wheat gluten and on defining immunomodulatory strategies to recover the oral tolerance to gluten in celiac disease…

Read More

Environmental security and human health

Group Leader : Ferdinando FebbraioTopics : Biochemistry   The studies of proteins, and recently also nucleic acids, are oriented to the development of their biotechnological applications such as molecular markers, bioreceptors in biosensors and bio-drugs.   Key Pubblications G.P. Cetrangolo, C. Gori, J. Rusko, S. Terreri, G. Manco, A. Cimmino, F. Febbraio, Determinationof Picomolar Concentrations…

Read More