laboratories

Group Leader: Francesca RubertiTopic : Neurobiology     Non-coding RNAs and in particular microRNAs tunes brain cell differentiation and synaptic development and modulates brain functions such as synaptic plasticity, memory formation and behavioral performance.Our research aims to identify long noncoding RNAs (lncRNAs) and/or microRNAs as well as their interactions, and to investigate their roles in…

Group Leader: Giovina RubertiTopics: Molecular oncology and pathology, Immunity and InfectionKey words: Cancer biology, Schistosome biology, target and drug discovery   Our laboratory is active in the fields of cancer biology and Schistosoma mansoni biology. By developing model systems and investigating complex biological processes we aim to identify targets and molecules relevant for unmet medical needs: cancer…

Group Leader : Manuela PellegriniTopic: Molecular oncology and pathologyKey words: Genomic/Genetic instability; ATM Gene therapy; Animal models;   Genomic instability is a key event of cancer. To preserve genomic stability cells have developped systems to detect and repair DNA double strand breaks (DSBs).DSBs occur in response to exogenous agents, such as chemoterpeutics and during physiological processes…

Group Leader : Maria Laura FalchettiTopic: Molecular oncology and pathology   The research focus of our lab is the brain tumor glioblastoma (GBM). Our research has evolved over time, but the characterizing red trail has always been GBM. We studied different aspects, some dealing with GBM tumor biology, others are therapy-oriented. GBM is the most…

Group Leader : Christian BarbatoKeywords : neurodegenerative disease; microRNAs; RNA-Binding ProteinsTopic : Neurobiology Study of the role of RNA-induced Silencing Complex (RISC), small non-coding RNA and RNA-binding proteins in nervous system. Biomarkers in neurological and cancer disease; Key Pubblications 1) Canu N, Dus L, Barbato C, Ciotti MT, Brancolini C, Rinaldi A, Novak M, Cattaneo A, Bradbury A…

Group leader : Maria Grazia Di CertoKeywords : Membrane dynamics, RNA metabolism, neuromuscular diseasesTopics : Neurobiology, Muscle physiology and pathology Our main research interest is to understand how RNA-related proteins impact cellular/tissue homeostasis in health and disease.Ongoing studies aim to assess the intriguing interplay between RNA metabolism and membrane trafficking regulating gene expression at subcellular level.…

Group Leader: Germana FalconeTopics : Muscle Biology and PathologyKeywords: muscle biopathology, nocoding RNAs, gene therapy Our research group has a wide long-standing experience in molecular and cellular biology of muscle cells, intracellular cell signaling in oncogenic transformation and differentiation, and post-transcriptional regulation of gene expression, particularly microRNA analysis and studies on microRNA-target interaction. In past…

Group Leader : Sara MarinelliKey words: autophagy, myelin, glia, disease-related biomarkers, immune cellsTopics : Neurobiology Our research group is involved in three main fields of study: A) Peripheral Neuropathies and Inflammatory Pain Nutrition, metabolic disorders, aging and gender-differences in incidence of neuropathic pain development: spinal and peripheral nerve mechanisms of inflammation and degeneration. New therapeutic…

Group Leader : Siro LuvisettoTopics: Neurobiology Exercise is a common and necessary component of rehabilitative therapy for functional recovery after traumatic injuries of peripheral nervous system. The onset of neuropathic pain is often a consequence of such traumatic events. A first aim of my research is to assess what protocol of treadmill exercise is effective…

Group Leader : Francesca R. D’amatoTopic: Neurobiology   The main object of my research is the evaluation of gene X environment interaction on behavioural phenotypes in the mouse.In particular I’m interested in the evaluation of emotional and social behaviors during development and at adulthood in mouse models of developmental psychopathologies. Mother-infant interaction and the effect…