Sara Marinelli

Research Area: Neurobiology


Monterotondo Scalo – Campus “A.Buzzati Traverso”
+39 06 90091477 (office)
sara.marinelli@cnr.it
Reserach Gate page
CNR – People

Neurodegeneration, Neuroinflammation and Pain 

Key words: autophagy, myelin, glia, disease-related biomarkers, immune cells

 

Our research group is involved in three main fields of study:

A) Peripheral Neuropathies and Inflammatory Pain

  • Nutrition, metabolic disorders, aging and gender-differences in incidence of neuropathic pain development: spinal and peripheral nerve mechanisms of inflammation and degeneration.
  • New therapeutic targets and new pharmacological tools against pain.
  • Botulinum neurotoxins: new therapeutic applications and mechanisms of action

B) Spinal Neurodegeneration

Drugs able to confer neuroprotection and stimulate regeneration in models of spinal cord injury.

C) Amyotrophic Lateral Sclerosis

Systemic, peripheral and central immune response during temporal progression of ALS neurodegeneration in SOD1-G93A mice: identification of new drivers

EXPERIMENTAL SYSTEMS and SKILLS

Murine (surgical, chemical and transgenic) models of peripheral and central neurodegeneration and metabolic disorders inducing inflammatory and neuropathic pain.

In vivo investigations

Behavioral tests: spontaneous and nociceptive behaviors; motor function and muscular force; learning and memory.

Metabolic analyses: Glucose and Insulin Tolerance test, metabolic parameters (glycemia, cholesterol, triglycerides, etc), biomarkers of organs (liver, bladder, kidney) functionality, thermoregulation.

Ex-vivo investigations

Nervous tissue (brain, spinal cord, dorsal root ganglia, peripheral nerve, nerve endings, neuromuscular junction) immunohistological, morphological analysis and proteins expression.

Samples of organs (blood and nervous, adipose, muscular tissues) for biochemical and molecular identification of biomarkers

Education

2001 Master, Sapienza University of Rome (Italy), Experimental Psychology

2002-2005 PhD, Sapienza University of Rome (Italy), Psychobiology and Psychopharmacology

2003 EUROPEAN PAIN SCHOOL. FENS, IBRO, EFIC University of Siena.

2006/2007 Post-doc position CNR Neuroscience Institute – Rome – Italy

2006 Advanced course PHYSIOLOGICAL IMAGING CNR. Neuroscience Institute, Scuola Normale Superiore, Pisa, Italy.

2007 Post-doc position. CNR Neuroscience Institute/Polish Academy of Science – Institute of Pharmacology – Krakow –PL

2010 Advanced course. STATISTICS IN ANIMALS EXPERIMENTS. CNR, Fondazione S. Lucia, AISAL, EBRI

2010 Advanced course. PATENTS AS TOOL OF STRATEGIC MANAGEMENT IN INTELLECTUAL PROPERTY. RIDITT – Ministero dello Sviluppo Economico – IPI (Istituto Promozione Industriale).

2007 and 2014 SCIENCE OF ANIMALS LAB. FELASA. CNR, IRCCS S. Lucia Foundation, Tor Vergata University of Rome, EBRI

2018 Advanced Course. USE OF “R” SOFTWARE FOR STATISTICS IN BIOMEDICINE RESEARCH. S. Lucia Foundation, CNR – Rome

2018 CNR Training Course. ERC GRANTS IN HORIZON 2020: rules of participation and assessment criteria. (2223660.2223667)

2019 CNR, APRE Training Course. WRITING WORKSHOP ON SUCCESSFUL PROPOSAL IN HORIZON 2020 PROGRAM. (3242262.3242269)

Positions : Researcher

Honours/Awards:

01/08/2005. Best poster presentation. Association for the Study of Pain (IASP) (Sydney – Australia);

01/09/2007 Travel grant SINS Verona; 01/02/2008 Young Ideas Change Italy – Presidency of the Council of Ministers – Ministry of Youth (POGAS);

01/03/2015 SIMPAR Award “Young Against Pain” 30 best projects in pain therapy;

01/09/2015 Art or Science – IMMAGINARIO SCIENTIFICO – Winner best scientific image – Exposition Trieste Next;

Patents:

A NEW THERAPEUTIC USE OF THE BOTULINUM NEUROTOXIN SEROTYPE A

Publication number: 20180140685
Abstract: A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, therapeutic treatment of paralysis caused by spinal cord injury.
Type: Application
Filed: April 21, 2016
Publication date: May 24, 2018
Applicant: Consiglio Nazionale Delle Ricerche
Inventors: Sara Marinelli, Flaminia Pavone, Siro Luvisetto, Valentina Vacca

Method for the potentiation of opioid analgesics effects on pain

Patent number: 8715666
Abstract: According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a medicament for treating and/or preventing pain.
Type: Grant
Filed: June 23, 2011
Date of Patent: May 6, 2014

Assignee: Lay Line Genomics S.p.A.

Inventors: Flaminia Pavone, Sara Marinelli, Antonio Cattaneo, Gabriele Ugolini

 

Analgesic treatment with prolonged effect

Patent number: 8691221

Abstract: Use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA, in particular capable of blocking the biological activity of TrkA, for the preparation of a medicament for treating and/or preventing chronic pain.

Type: Grant

Filed: June 7, 2006

Date of Patent: April 8, 2014

Assignee: Lay Line Genomics S.p.A.

Inventors: Flaminia Pavone, Sara Marinelli, Antonio Cattaneo, Gabriele Ugolini

METHOD FOR THE POTENTIATION OF OPIOID ANALGESICS EFFECTS ON PAIN

Publication number: 20120213784

Abstract: According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a medicament for treating and/or preventing pain.

Type: Application

Filed: June 23, 2011

Publication date: August 23, 2012

Applicant: LAY LINE GENOMICS S.p.A.

Inventors: FLAMINIA PAVONE, SARA MARINELLI, ANTONIO CATTANEO, GABRIELE UGOLINI

Cnf1 bacterial toxin protein from e. coli as analgesic

EP06796248A

Abstract

The invention concerns new uses in medical field of the dermonecrotizing protein factors of bacterial origin, particularly from Escherichia coli and related uses in medical field.

Type:Grant

Filed: August 3, 2006

Applicant: Consiglio Nazionale delle Richerche CNR Istituto Superiore di Sanita

Inventors: Walter Malorni, Carla Fiorentini, Alessia Fabbri, Loredana Falzano, Elisabetta Straface, Flaminia Pavone Siro Luvisetto, Sara Marinelli

 

Novel Analgesic Treatment with Prolonged Effect

Publication number: 20100291083

Abstract: Use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA, in particular capable of blocking the biological activity of TrkA, for the preparation of a medicament for treating and/or preventing chronic pain.

Type: Application

Filed: June 7, 2006

Publication date: November 18, 2010

Applicant: NOVARTIS VACCINES AND DIAGONOSTICS

Inventors: Flaminia Pavone, Sara Marinelli, Antonio Cattaneo, Gabriele Ugolini

  1. De Angelis, F., Vacca, V., Pavone, F., Marinelli, S. Impact of caloric restriction on peripheral nerve injury-induced neuropathic pain during ageing in mice (2020) European Journal of Pain, 24 (2), pp. 374-382.
  2. Marinelli, S., Vacca, V., Angelis, F.D., Pieroni, L., Orsini, T., Parisi, C., Soligo, M., Protto, V., Manni, L., Guerrieri, R., Pavone, F. Innovative mouse model mimicking human-like features of spinal cord injury: efficacy of Docosahexaenoic acid on acute and chronic phases (2019) Scientific Reports, 9 (1), 8883.
  3.  Coccurello, R., Nazio, F., Rossi, C., De Angelis, F., Vacca, V., Giacovazzo, G., Procacci, P., Magnaghi, V., Ciavardelli, D., Marinelli, S. Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice (2018) PLoS ONE, 13 (12), e0208596.
  4. Madaro, L., Passafaro, M., Sala, D., Etxaniz, U., Lugarini, F., Proietti, D., Alfonsi, M.V., Nicoletti, C., Gatto, S., De Bardi, M., Rojas-García, R., Giordani, L., Marinelli, S., Pagliarini, V., Sette, C., Sacco, A., Puri, P.L. Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis. (2018) Nature Cell Biology, 20 (8), pp. 917-927.
  5. Finocchiaro, A., Marinelli, S., De Angelis, F., Vacca, V., Luvisetto, S., Pavone, F. Botulinum toxin b affects neuropathic pain but not functional recovery after peripheral nerve injury in a mouse model. (2018) Toxins, 10 (3), 128.

View all publications

Researchers:

Post-doctoral fellows:

  • Valentina Vacca

  • GIOVANI RICERCATORI
  • INTERNATIONAL ASSOCIATION FOR STUDY OF PAIN