Giuliana Catara

Research Area: Biochemistry


Napoli – Research Area NA1
+39 081 6132565 (office)
+39 081 6132492 (lab)
giuliana.catara@ibbc.cnr.it
giuliana.catara
ORCID

Keywords: Hydrolases; Protein post-translational modifications; biotechnology for human health.

  • Characterization of small molecules with anti-tumoral activity (see Corda’s lab page); Identification of bioactive molecules from antarctic marine and freshwater eukaryotic biodiversity (see Coscia’s lab page);
  • Biochemical characterization of enzymes involved in protein post-translational modifications (ADP-ribosylation and Ubiquitination) and their role in response to stressful conditions (see Corda’s lab page);
  • Purification and characterization of NAD+ metabolites deriving from NAD+-dependent enzymes activity (see Corda’s Lab page);
  • Biochemical characterization of enzymes (proteases, b-glycosidases) from mesophilic microorganisms (bacteria and yeasts) and from thermophilic Archaea and their application in biotechnological fields (bioremediation, agro-industrial processes, biological control of post-harvest disease in host-pathogen interaction

Education:

2008                          Qualification to the biologist profession

1999                          PhD in Biochemistry and Molecular Biology, University of Catania

1998-1996                Programme of Doctorate in Biochemistry and Molecular Biology, University of Catania, Italy

1995                         Degree in Biological Sciences, Summa cum laude University of Catania

 

Positions:

2018-present                       In charge of science communication at Institute of Biochemistry and Cell Biology

2009-present                       Full time researcher at Institute of Biochemistry and Cell Biology (formerly Institute of Protein Biochemistry)

 

Honours/Awards:

2007-2008               Post-doc fellowship at Institute of Protein Biochemistry (IBP), CNR, Napoli,

2006-2007               Post-doc Fellowship at IBP, CNR, Napoli, 2006-2007 (Technology Innovation to meliorate Agro-food processes and Products for PMIs)

2004-2006               Post-doc Fellowship at IBP, CNR, Napoli, (Proteases from thermophilic microorganisms)

2001-2003               Post-doc Fellowship University of Naples Federico II, Napoli, (Cloning and expression of enzymes from hyperthermophilic Archaea)

1999-2001               Post-doc Fellowship at Institute of Protein Biochemistry and Enzimology (IBPE), National Council of Research (CNR), Napoli, (EU project “Inactivation of causative agents of transmissible spongiform encephalopathies by thermophilic and hyperthermophilic proteases”)

1999                          Post-doc Fellowship at the Department of Animal Biology and Genetics, Firenze University, Firenze, (EU project EUROFAN)

1999                          Post-doc Fellowship Consorzio Catania Ricerche (Heterologous protein expression in yeasts of agro-industrial interest)

 

Patents:

Rossi M, Catara G, Palmieri G. Un nuovo inibitore proteico delle proteasi. Brevetto italiano N. Domanda NA2008A000060 del 23/10/2008

Rif. CNR 10003 – Domanda di Brevetto USA No. 13/778,734 DIVISIONALE della dom. No. 13/093,199- PCT/IT2009/000478 “PROTEASES TARGETING AGENTS” (dom Italia No. NA2008A000060) Rossi M.,Catara G., Palmieri G., Ruvo M., – Ns rif.: 7333/MS/ps

1.T. Carusone, G. Cardiero , M. Cerreta, L. Mandrich, O. Moran, E. Porzio, G. Catara, G. Lacerra, and G. Manco WTAP and BIRC3 are Involved in the Posttranscriptional Mechanisms that Impact on the Expression and Activity of the Human Lactonase PON2
Cell Death and Disease 2020 in press.

2.Catara G, Corteggio A, Valente C, Grimaldi G, Palazzo L. Targeting ADP-ribosylation as antimicrobial strategy Biochem Pharmacol. 2019, Sep;167:13-26.

3.Grimaldi G, Catara G, Palazzo L, Corteggio A, Valente C, Corda D.PARPs and PAR as novel pharmacological strategy for the treatment of stress granule-associated disorders. Biochem. Biochem Pharmacol. 2019 Sep;167:64-75.

4.G. Catara, G. Grimaldi, L.Schembri, D. Spano, G. Turacchio, M. Lo Monte, A.R. Beccari, C. Valente, D. Corda PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions. 2017 Scientific Reports7, 14035.

5.Colanzi A., Grimaldi G., Catara G., et al., Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. 2013, PNAS, 110 (24), 9794–9799

view all pubications

  1. Carusone , G. Cardiero , M. Cerreta, L. Mandrich, O. Moran , E. Porzio, G. Catara, G. Lacerra, and G. Manco WTAP and BIRC3 are Involved in the Posttranscriptional Mechanisms that Impact on the Expression and Activity of the Human Lactonase PON2
    Cell Death and Disease 2020 in press.
  2. Catara G, Corteggio A, Valente C, Grimaldi G, Palazzo L. Targeting ADP-ribosylation as antimicrobial strategy Biochem Pharmacol. 2019 Sep;167:13-26.
  3. Grimaldi G, Catara G, Palazzo L, Corteggio A, Valente C, Corda D.PARPs and PAR as novel pharmacological strategy for the treatment of stress granule-associated disorders. Biochem. Biochem Pharmacol. 2019 Sep;167:64-75.
  4. Grimaldi, G. Catara, C. Valente, D. Corda In vitro tecniques for ADP-ribosylated substrate identification, Methods Mol Biol. 2018;1813:25-40.
  5. Catara, G. Grimaldi, L.Schembri, D. Spano, G. Turacchio, M. Lo Monte, A.R. Beccari, C. Valente, D. Corda PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions. 2017 Scientific Reports7, 14035.
  6. Grimaldi G, Corda D., Catara G. From toxins to mammalian enzymes: the diversity of mono-ADP-ribosylation 2015 Front Biosci (Landmark Ed) 20:389-404.
  7. Colanzi A., Grimaldi G., Catara G., et al., Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. 2013, PNAS, 110 (24), 9794–9799.
  8. Balestrieri M, Gogliettino M, Fiume I, Pocsfalvi G, Catara G, Rossi M, Palmieri G. Structural and functional insights into Aeropyrum pernix OppA, a member of a novel archaeal OppAsubfamily 2011 J Bacteriology 193: 620-630.
  9. R Cannio, G Catara, I Fiume, M Balestrieri, M Rossi, G Palmieri 2010 Identification of a cell-bound extracellular protease overproduced by Sulfolobus solfataricus in peptide-rich media. Protein and peptide letters 17 (1), 78-85.
  10. De Luca V, Maria G, De Mauro G, Catara G, Carginale V, Ruggiero, G, Capasso A, Parisi E, Brier S, Engen JR, Capasso C. Aspartic proteinases in Antarctic fish 2009. Marine Genomics 2: 1-10.
  11. Palmieri, G. Catara, et al., (co-authoring) First archaeal PEBP-Serine protease inhibitor from Sulfolobus solfataricus with noncanonical amino acid sequence in the reactive site loop. 2009 J. of Proteome Research, 8, 327-334.
  12. Tessitori M, Maria G, Capasso C, Catara G, Rizza S, De Luca V, Catara A, Capasso A, Carginale V. Differential display analysis of gene expression in Etrog citron leaves infected by Citrus viroid III. Biochim Biophys Acta. 2007 Apr;1769(4):228-35.
  13. G Palmieri, A Casbarra, I Fiume, G Catara, A Capasso, G Marino, S Onesti, M. Rossi. 2006 Identification of the first archaeal oligopeptide-binding protein from the hyperthermophile Aeropyrum pernix. Extremophiles 10 (5), 393-402-
  14. G Catara, I Fiume, F Iuliano, G Maria, G Ruggiero, G Palmieri, A Capasso, M. Rossi.A new kumamolisin-like protease fromAlicyclobacillus acidocaldarius: an enzyme active under extreme acidic conditions 2006. Biocatalysis and Biotransformation 24 (5), 358-370
  15. Palmieri, A. Casbarra, G. Marino, G. Catara, G. Ruggiero, A. Capasso, M. Rossi. High cleavage specificity of a subtilisin-like protease from a hyperthermophilic archaeon under extreme conditions. 2005 Enzyme and Microbial Technology, 37, 745-749.
  16. Catara G., Ruggiero G., La Cara F., Digilio F.A., Capasso A., Rossi M. A novel extracellular subtilisin-like protease from the hyperthermophile Aeropyrum pernix K1: biochemical properties, cloning and expression. 2003, Extremophiles 7, 391 399.
  17. Rizza, C. Capasso, G. Catara,, A. Capasso, E. Conte, A. Catara. Transcriptional Response of Troyer Citrange, Sour Orange and Alemow Rootstocks to Citrus viroid IIIb (CVd-IIIb) Infection Journal International Organization of Citrus Virologists Conference Proceedings (1957-2010), 17(17).