Silvia Middei

Research Areas: Neurobiology

Monterotondo Scalo – Campus “A.Buzzati Traverso”
Research Gate Page
silvia.middei@cnr.it
People – CNR
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My background is in Experimental Psychology, and I have more that 20-years expertise in phenotyping mouse models for neurological diseases. During my two Post-Docs and the early years as CNR researcher, I have focused my studies on synaptic plasticity, and I gained expertise in electrophysiology and molecular biology. My research topic was on Alzheimer’s Disease (AD), with particular interest toward the neurobiological events at early stages of the pathology.

My team and I clarified how synaptic networks in key brain regions can re-arrange to compensate for relevant synaptic degeneration and to maintain intact cognition at the onset of AD (Pignataro et al, Bilogical Psychiatry 2018). More recently, we elucidated the mechanisms through which seizures enhance the risk to develop AD and we proposed the repurposing of an antiepilectic drug in the theraphy of AD (Rizzello et al., Neurobiology of Disease 2023).

Over the last few years, I’ve started studies at the intersection of cancer and neurobiology. In collaboration with researcher at CNR Neuroscience Institute (Pisa, Italy), I have characterized the neuronal morphology in peritumoral glioma of rodents (Vannini et al., Neuro-Oncology, 2016).

In a more recent study (Middei et al, Biomolecules 2022), I demonstrated that enhancing maternal care in rodent pups can have a long-term protective effect and delay the occurrence of tumors experimentally induced in adulthood. Together with my colleagues at Institute of Biochemistry and Cell Biology (Monterotondo, Italy), we further identified possible molecular mechanisms through which maternal care protects from tumors. A deeper investigation of these mechanisms is the aim of my current research.

Education

 2001-2005            PhD in Neuroscience, University Tor Vergata (Rome, Italy)

1993-1998             Master Degreee in Experimental Psychology, University La Sapienza Faculty of Psychology (Rome, Italy)

Positions

2023-current     Senior Researcher, National Research Council, Institute of Biochemistry and        Cell Biology, (Monterotondo, Italy)

2011- 2023            Research Scientist, National Research Council, Institute of Biochemistry and Cell Biology- former Institute of Neurobiology and Cel Biology (Monterotondo, Italy)

2007-2011             Research Assistant, Santa Lucia Foundation Psychobiology, (Rome, Italy)

2005-2007              Post Doc, Trinity College Institute of Neuroscience, (Dublin, Ireland)

2000-2004              PhD Student, Santa Lucia Foundation Psychobiology, (Rome, Italy)

Honors

IRCSET Embark Initiative Long Term fellowship at Trinity College Dublin (Ireland), (2005)

Societa’ Italiana di Neuroscienze (Italian Society for Neuroscience), Travel Award (2005)

European Science Foundation Travel Award (2004)

Selected participant for FENS/Hertie Foundation Winter School (2004)

European Science Foundation Travel Award (2002)

Advisor and Committee

Scientific Advisory Board member

Alzheimer’s Research Trust

Alzheimer’s Association.

Peer-reviewer

Journal of Biophotonics, International Journal of Molecular Sciences, Plos One, Scientific Reports, Neural Plasticity, Frontiers in Behavioral Neurosciences, Applied Sciences, Brain research Bullettin

Guest Editor

Brain Sciences

Neural Plasticity

 

Scientific Organisation Committee

Member of organizing committee for the IBBC conference Preclinical models of human disease (Monterotondo, 18-19 January 2023).

 

Memberships

Italian Society for Neurosciences

Federation of European Neurosciences

Society for Neuroscience (USA)

European Brain and Behaviour Society

 

Teaching activity and PhD evaluation commitee

Teaching activity

2019-current         International College of Osteopathic Medicine; Via Sant’Anna (Rome, Italy)

2008-2010             Lumsa University; Via della Transpontina (Rome, Italy)

2003- 2005            Sapienza University; Piazzale Aldo Moro (Rome, Italy)

 

PhD evaluation committee

Sapienza University, Rome (Italy). PhD School in Neuroscience, PhD Program in Behavioral Neuroscience.

University of Bordeaux (France). Doctoral School of Life and Health Sciences, Speciality Neuroscience -and- University of Catania (Italy). International PhD program in Neuroscience (XXXIII Cycle).

 

 

  • Publications as corresponding author* and most relevant publications:

    1. Rizzello E, Pimpinella D, Pignataro A, Titta G, Merenda E, Saviana M, Porcheddu GF, Paolantoni C, Malerba F, Giorgi C, Curia G, Middei S*, Marchetti C. Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer’s disease mouse model. Neurobiol Dis. 2023 Jun 1;181:106106.
    2. Middei S*, Giorgini L, Vacca V, Storri F, Putti S, Strimpakos G, Raspa M, Scavizzi F, Moretti F, D’Amato FR. Early Social Enrichment Modulates Tumor Progression and p53 Expression in Adult Mice. 2022 Mar 31;12(4):532.
    3. Middei S*. Neuroimaging Applications for Diagnosis and Therapy of Pathologies in the Central and Peripheral Nervous System. Brain Sci. 2022 Feb 1;12(2):207.
    4. Farioli-Vecchioli S, Ricci V, Middei S*. Adult Hippocampal Neurogenesis in Alzheimer’s Disease: An Overview of Human and Animal Studies with Implications for Therapeutic Perspectives Aimed at Memory Recovery. Neural Plast. 2022 Jan 15;2022:9959044.
    5. Torcinaro A, Ricci V, Strimpakos G, De Santa F, Middei S*. Peripheral Nerve Impairment in a Mouse Model of Alzheimer’s Disease. Brain Sci. 2021 Sep 20;11(9):1245.
    6. Rizzello E, Middei S*,Marchetti C Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer’s Disease. Curr Alzheimer Res. 2020 Feb 24:10.2174/1567205017666200224122113
    7. Scopa C, Marrocco F, Latina V, Ruggeri F, Corvaglia V, La Regina F, Ammassari-Teule M, Middei S, Amadoro G, Meli G, Scardigli R, Cattaneo A. Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers. Cell Death Differ. 2020 Mar;27(3):934-948.
    8. Pignataro A, Meli G, Pagano R, Fontebasso V, Battistella R, Conforto G, Ammassari-Teule M, Middei S*. Activity-Induced Amyloid-β Oligomers Drive Compensatory Synaptic Rearrangements in Brain Circuits Controlling Memory of Presymptomatic Alzheimer’s Disease Mice. Biol Psychiatry. 2019 Aug 1;86(3):185-195
    9. Pignataro A, Middei S*. Trans-Synaptic Spread of Amyloid-β in Alzheimer’s Disease: Paths to β-Amyloidosis. Neural Plast. 2017;2017:5281829.
    10. Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Kheirollahi-Chadegani M, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Keskivali-Bond P, Wells S, Cater H, Fort P, Santibanez-Koref M, Middei S, Sette C, Clowry GJ, Barash Y, Cunningham MO, Elliott DJ. A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior. Cell Rep. 2016 Dec 20;17(12):3269-3280.
    11. Antonelli R, De Filippo R, Middei S, Stancheva S, Pastore B, Ammassari-Teule M, Barberis A, Cherubini E, Zacchi P. Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95. J Neurosci. 2016 May 18;36(20):5437-47.
    12. Vannini E, Olimpico F, Middei S, Ammassari-Teule M, de Graaf EL, McDonnell L, Schmidt G, Fabbri A, Fiorentini C, Baroncelli L, Costa M, Caleo M. Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function. Neuro Oncol. 2016 Dec;18(12):1634-1643.
    13. Oddi D, Subashi E, Middei S, Bellocchio L, Lemaire-Mayo V, Guzmán M, Crusio WE, D’Amato FR, Pietropaolo S. Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology. 2015 Mar 13;40(5):1113-22.
    14. Pignataro A, Borreca A, Ammassari-Teule M, Middei S*. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex. Neural Plast. 2015; 2015:651469.
    15. Errico F, Nisticò R, Di Giorgio A, Squillace M, Vitucci D, Galbusera A, Piccinin S, Mango D, Fazio L, Middei S, Trizio S, Mercuri NB, Teule MA, Centonze D, Gozzi A, Blasi G, Bertolino A, Usiello A. Free D-aspartate regulates neuronal  dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals. Transl Psychiatry. 2014 Jul 29;4:e417.
    16. Middei S, Ammassari-Teule M, Marie H. Synaptic plasticity under learning challenge. Neurobiol Learn Mem. 2014 Nov;115:108-15.
    17. Middei S, Houeland G, Cavallucci V, Ammassari-Teule M, D’Amelio M, Marie H. CREB is necessary for synaptic maintenance and learning-induced changes of the AMPA receptor GluA1 subunit. Hippocampus. 2013 Jun;23(6):488-99.
    18. Middei S, Spalloni A, Longone P, Pittenger C, O’Mara SM, Marie H, Ammassari-Teule M. CREB selectively controls learning-induced structural remodeling of neurons. Learn Mem. 2012 Jul 18;19(8):330-6.
    19. D’Amelio M, Cavallucci V, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P, Battistini L, Moreno S, Bacci A, Ammassari-Teule M, Marie H, Cecconi F. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer’s disease.  Nat Neurosci. 2011 Jan;14(1):69-76.
    20. Middei S*, Roberto A, Berretta N, Panico MB, Lista S, Bernardi G, Mercuri NB, Ammassari-Teule M, Nisticò R. Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer’s disease. Learn Mem. 2010 Apr 19;17(5):236-40
    21. Marchetti C, Tafi E, Middei S, Rubinacci MA, Restivo L, Ammassari-Teule M, Marie H. Synaptic adaptations of CA1 pyramidal neurons induced by a highly effective combinational antidepressant therapy. Biol Psychiatry. 2010 Jan 15;67(2):146-54.
    22. Middei S*, Restivo L, Caprioli A, Aceti M, Ammassari-Teule M. Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease. Neurobiol Learn Mem. 2008 Sep;90(2):467-71.
    23. Middei S*, Vetere G, Sgobio C, Ammassari-Teule M. Landmark-based but not vestibular-based orientation elicits mossy fibers  synaptogenesis in the mouse hippocampus.  Neurobiol Learn Mem. 2007 Feb;87(2):174-80.
    24. Bellenchi GC, Gurniak CB, Perlas E, Middei S, Ammassari-Teule M, Witke W. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007 Sep 15;21(18):2347-57.
    25. Middei S, Daniele S, Caprioli A, Ghirardi O, Ammassari-Teule M. Progressive cognitive decline in a transgenic mouse model of Alzheimer’s disease overexpressing mutant hAPPswe. Genes Brain Behav. 2006 Apr;5(3):249-56.
    26. Middei S, Restivo L, Sgobio C, Passino E, Ammassari-Teule M. Reversible inactivation of hippocampus and dorsolateral striatum in C57BL/6 and DBA/2 inbred mice failed to show interaction between memory systems in these genotypes. Behav Brain Res. 2004 Oct 5;154(2):527-34.
    27. Middei S*, Geracitano R, Caprioli A, Mercuri N, Ammassari-Teule M. Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer’s disease overexpressing mutant hAPPswe. Learn Mem. 2004 Jul-Aug;11(4):447-52.

    View all publications.

    https://pubmed.ncbi.nlm.nih.gov/?term=middei%20s&sort=date&ac=yes

Publications as corresponding author:    

  1. Rizzello E, Middei S,Marchetti C Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer’s Disease. Curr Alzheimer Res. 2020 Feb 24:10.2174/1567205017666200224122113
  2. Pignataro A, Meli G, Pagano R, Fontebasso V, Battistella R, Conforto G, Ammassari-Teule M, Middei S. Activity-Induced Amyloid-β Oligomers Drive Compensatory Synaptic Rearrangements in Brain Circuits Controlling Memory of Presymptomatic Alzheimer’s Disease Mice. Biol Psychiatry. 2019 Aug 1;86(3):185-195
  3. Pignataro A, Middei S. Trans-Synaptic Spread of Amyloid-β in Alzheimer’s Disease: Paths to β-Amyloidosis. Neural Plast. 2017;2017:5281829.
  4. Pignataro A, Borreca A, Ammassari-Teule M, Middei S. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex. Neural Plast. 2015;2015:651469.
  5. Middei S, Houeland G, Cavallucci V, Ammassari-Teule M, D’Amelio M, Marie H. CREB is necessary for synaptic maintenance and learning-induced changes of the AMPA receptor GluA1 subunit. Hippocampus. 2013 Jun;23(6):488-99.
  6. Middei S, Spalloni A, Longone P, Pittenger C, O’Mara SM, Marie H, Ammassari-Teule M. CREB selectively controls learning-induced structural remodeling of neurons. Learn Mem. 2012 Jul 18;19(8):330-6.
  7. Middei S, Roberto A, Berretta N, Panico MB, Lista S, Bernardi G, Mercuri NB, Ammassari-Teule M, Nisticò R. Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer’s disease. Learn Mem. 2010 Apr 19;17(5):236-40
  8. Middei S, Restivo L, Caprioli A, Aceti M, Ammassari-Teule M. Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease. Neurobiol Learn Mem. 2008 Sep;90(2):467-71.
  9. Middei S, Vetere G, Sgobio C, Ammassari-Teule M. Landmark-based but not vestibular-based orientation elicits mossy fiber synaptogenesis in the mouse hippocampus. Neurobiol Learn Mem. 2007 Feb;87(2):174-80.
  10. Middei S, Daniele S, Caprioli A, Ghirardi O, Ammassari-Teule M. Progressive cognitive decline in a transgenic mouse model of Alzheimer’s disease overexpressing mutant hAPPswe. Genes Brain Behav. 2006 Apr;5(3):249-56.

Other publications:

  1. Scopa C, Marrocco F, Latina V, Ruggeri F, Corvaglia V, La Regina F, Ammassari-Teule M, Middei S, Amadoro G, Meli G, Scardigli R, Cattaneo A.Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers. Cell Death Differ. 2020 Mar;27(3):934-948.
  2. Nicolis di Robilant V, Scardigli R, Strimpakos G, Tirone F, Middei S, Scopa C, De Bardi M, Bttistini L, Saraulli D, Farioli Vecchioli S. Running-activated  neural stem cells enhance subventricular neurogenesis and improve  olfactory behaviour in p21 knockout mice. Mol Neurobiol. 2019 Nov;56(11):7534-7556
  3. Borreca A, Latina V, Corsetti V, Middei S, Piccinin S, Della Valle F, Bussani R, Ammassari-Teule M, Nisticò R, Calissano P, Amadoro G. AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy. Mol Neurobiol. 2018 Oct;55(10):8124-8153.
  4. Pignataro A, Pagano R, Guarneri G, Middei S, Ammassari-Teule M. Extracellular matrix controls neuronal features that mediate the persistence of fear. Brain Struct Funct. 2017 Dec;222(9):3889-3898.
  5. Criscuolo C, Fontebasso V, Middei S, Stazi M, Ammassari-Teule M, Yan S, Origlia N. Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model. Sci Rep 2017 Feb 13; (7): 42370
  6. Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Kheirollahi-Chadegani M, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Keskivali-Bond P, Wells S, Cater H, Fort P, Santibanez-Koref M, Middei S, Sette C, Clowry GJ, Barash Y, Cunningham MO, Elliott DJ. A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior. Cell Rep. 2016 Dec 20;17(12):3269-3280.
  7. Vannini E, Olimpico F, Middei S, Ammassari-Teule M, de Graaf EL, McDonnell L, Schmidt G, Fabbri A, Fiorentini C, Baroncelli L, Costa M, Caleo M. Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function. Neuro Oncol. 2016 Dec;18(12):1634-1643.
  8. Antonelli R, De Filippo R, Middei S, Stancheva S, Pastore B, Ammassari-Teule M, Barberis A, Cherubini E, Zacchi P. Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95. J Neurosci. 2016 May 18;36(20):5437-47.
  9. Vannini E, Restani L, Pietrasanta M, Panarese A, Mazzoni A, Rossetto O, Middei S, Micera S, Caleo M. Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks. Brain Struct Funct. 2016 Jul;221(6):2919-36.
  10. Oddi D, Subashi E, Middei S, Bellocchio L, Lemaire-Mayo V, Guzmán M, Crusio WE, D’Amato FR, Pietropaolo S. Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology. 2015 Mar 13;40(5):1113-22.
  11. Middei S, Ammassari-Teule M, Marie H. Synaptic plasticity under learning challenge. Neurobiol Learn Mem. 2014 Nov;115:108-15.
  12. Errico F, Nisticò R, Di Giorgio A, Squillace M, Vitucci D, Galbusera A, Piccinin S, Mango D, Fazio L, Middei S, Trizio S, Mercuri NB, Teule MA, Centonze D, Gozzi A, Blasi G, Bertolino A, Usiello A. Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals. Transl Psychiatry. 2014 Jul 29;4:e417.
  13. Pignataro A, Middei S, Borreca A, Ammassari-Teule M. Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice. Front Behav Neurosci. 2013 Oct 29;7:156.
  14. Pignatelli M, Vollmayr B, Richter SH, Middei S, Matrisciano F, Molinaro G, Nasca C, Battaglia G, Ammassari-Teule M, Feligioni M, Nisticò R, Nicoletti F, Gass P. Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats. Neuropharmacology. 2013 Mar;66:339-47.
  15. D’Amelio M, Cavallucci V, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P, Battistini L, Moreno S, Bacci A, Ammassari-Teule M, Marie H, Cecconi F. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer’s disease. Nat Neurosci. 2011 Jan;14(1):69-76.
  16. Marchetti C, Tafi E, Middei S, Rubinacci MA, Restivo L, Ammassari-Teule M, Marie H. Synaptic adaptations of CA1 pyramidal neurons induced by a highly effective combinational antidepressant therapy. Biol Psychiatry. 2010 Jan 15;67(2):146-54.
  17.  Vergni D, Castiglione F, Briani M, Middei S, Alberdi E, Reymann KG, Natalini R, Volonté C, Matute C, Cavaliere F. A model of ischemia-induced neuroblast activation in the adult subventricular zone. PLoS One. 2009;4(4):e5278.
  18. Giampà C, Middei S, Patassini S, Borreca A, Marullo F, Laurenti D, Bernardi G, Ammassari-Teule M, Fusco FR. Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease. Eur J Neurosci. 2009 Mar;29(5):902-10.
  19. Bellenchi GC, Gurniak CB, Perlas E, Middei S, Ammassari-Teule M, Witke W. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007 Sep 15;21(18):2347-57.
  20. Ognibene E, Middei S, Daniele S, Adriani W, Ghirardi O, Caprioli A, Laviola G. Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer’s disease. Behav Brain Res. 2005 Jan 30;156(2):225-32.
  21. Middei S, Restivo L, Sgobio C, Passino E, Ammassari-Teule M. Reversible inactivation of hippocampus and dorsolateral striatum in C57BL/6 and DBA/2 inbred mice failed to show interaction between memory systems in these genotypes. Behav Brain Res. 2004 Oct 5;154(2):527-34.
  22. Middei S, Geracitano R, Caprioli A, Mercuri N, Ammassari-Teule M. Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer’s disease overexpressing mutant hAPPswe. Learn Mem. 2004 Jul-Aug;11(4):447-52.
  23. Restivo L, Middei S, Mingfu L, Reggio R, Passino E, Formisano R, Ammassari-Teule M. Potentiation of ischemia-related behavioral alterations by electro-acupuncture in gerbils. Funct Neurol. 2004 Jan-Mar;19(1):19-23
  24. Ammassari-Teule M, Middei S, Passino E, Restivo L. Enhanced procedural learning following beta-amyloid protein (1-42) infusion in the rat. Neuroreport. 2002 Sep 16;13(13):1679-82.
  25. Aversano M, Ciamei A, Cestari V, Passino E, Middei S, Castellano C. Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of GABAergic mechanisms. Neurobiol Learn Mem. 2002 May;77(3):327-37.
  26. Passino E, Middei S, Restivo L, Bertaina-Anglade V, Ammassari-Teule M. Genetic approach to variability of memory systems: analysis of place vs. responselearning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice. Hippocampus. 2002;12(1):63-75.
  27. Restivo L, Passino E, Middei S, Ammassari-Teule M. The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA mice. Brain Res Bull. 2002 Jan 1;57(1):35-9

Research Support

Ongoing

CNR Research Grant (Italy). Healthy Ageing (DSB.AD006.371). Role in the project: PI. Years 2023-2024.

MUR PRIN Grant (Italy). Characterization and modulation of “immature” neurons: a potentially exploitable    reservoir of non-newly generated cells involved in plasticity of the rodent and human cerebral cortex. Role in the project: Participant. Years 2023-2025.

CNR Short term mobility grant (Italy). Study the impact of childhood parental relations on cancer in adulthood. Role in the project: PI. Year 2023.

Pending

Associazione Italiana Ricerca sul Cancro (Italy). Project title: Maternal care protects offspring from tumors in adulthood, role of p21WAF1/Cip1 through catecholamine signaling. Role: PI.

Worldwide Cancer Research (UK). Project title: Maternal care protects from tumors in adulthood, role of p21waf/Cip1 through well-being signals in the body. Role: PI.

Completed

Ministry of Health (Italy). Erasing fear in post-traumatic stress disorder: monitoring neuronal connectivity in hippocampal cortical networks during reconsolidation or extinction of remote aversive memories (RF-2009-1536072). Role in the project: Collaborator. Years 2009-2011.

Alzheimer Association Grant (USA). Preventing and monitoring onset of synaptic degeneration in early Alzheimer’s Disease (NIRG-11-204588). Role in the project: Collaborator. Years 2011-2013.

FILAS, Starting Grant (Italy). Sviluppo delle ricerche sul cervello: Aspetti molecolari e comportamentali delle malattie del Sistema Nervoso (DSB.AD004,089). Role in the project: Unit PI. Years 2011-2014.

CNR Research Grant (Italy). Disease mechanisms of working memory load capacity in ageing and Alzheimer’s Disease (AGESPAM IGB-CNR). Role in the project: Collaborator. Years 2012-2016.

Alzheimer Association Grant (USA). Learning from epilepsy to understand Alzheimer’s Disease (NIRG-12-237009). Role in the project: co-PI. Years 2012-2014.

CNR Short term mobility grant (Italy). Modulation of Oxytocin system in a mouse model of  Fragile X Syndrome. Role in the project: PI. Year 2018.

 

http://www.rainews.it/dl/rainews/articoli/Alzheimer-scoperta-molecola-ringiovanimento-cervello-fondazione-Ebri-90ec8de4-d399-479f-91f3-8ae85b7832fc.html

https://www.tgcom24.mediaset.it/salute/alzheimer-scoperta-la-molecola-che-blocca-la-malattia_11590515-201902a.shtml

https://tg24.sky.it/salute-e-benessere/2019/11/25/alzheimer-molecola-blocca-malattia.html

http://www.ansa.it/canale_saluteebenessere/notizie/medicina/2019/11/25/-alzheimer-scoperta-molecola-che-blocca-la-malattia-_daff9d84-16de-40b5-aef4-72a11a160372.html

https://www.ilsole24ore.com/art/alzheimer-scoperta-molecola-che-blocca-malattia-topi-ACD6UH1

https://www.repubblica.it/salute/medicina-e-ricerca/2019/11/25/news/alzheimer_scoperta_molecola_che_blocca_la_malattia-241908303/

https://www.research4life.it/alzheimer-i-ricercatori-italiani-scoprono-molecola-che-puo-bloccare-la-malattia/