Special Issue – Cells

Dear all,

I am hosting the Special Issue “Molecular and Signaling Networks in Cancer Development and Progression” together with Dr. Giuseppina Comito (Department of Experimental and Clinical Biomedical Sciences, University of Florence) published in collaboration with Cells (IF 4.366).

As the guest editors, we sincerely invite you to contribute a full research paper or review article for peer-review and possible publication in our special issue.
Over recent decades, various studies have argued that cancer development and progression are caused by the intrinsic properties of cancer cells, which are the result of the accumulation of both genetic and epigenetic alterations and alterations of the molecular and signaling pathways of tumor cells. Developmental signaling pathways, signaling transduction pathways, and cell cycle checkpoints are frequently dysregulated in cancer. However, recent evidence suggests that cancer development and malignant progression are also the result of the bidirectional, dynamic, and intricate complex interactions between the cells of the stromal tissue and cancer cells in the tumor microenvironment. Tumor cells recruit and activate nonmalignant cells of stromal tissue, which acquire a protumoral phenotype and, in turn, respond by secreting several factors that produce a unique microenvironment that can modify the neoplastic properties of the tumor cells. In turn, the tumor cells feed signals back to the stroma, thus contributing to the further modification of the tumor microenvironment. Therefore, cancer development and malignant progression are the results of both the intrinsic and extrinsic signaling networks of tumor cells.

In this Special Issue of Cells, we would like to include original research and review articles that contribute to the unraveling of the intrinsic and extrinsic signaling networks altered in cancer with the aim of promoting the exchange of ideas, concepts, and findings in this area of cancer. These findings represent an important issue for both dissecting the molecular bases of cancer and the development of new therapeutic agents that can fight both the initiation and recurrence of cancer. All scientists working in this field are cordially invited to submit their manuscripts.

The manuscript submission deadline is December 31st, 2021.

Please note that all contributions to this Special Issue must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.

You can find more information on this Special Issue, as well as the links to submit your manuscript, via the link: https://www.mdpi.com/journal/cells/special_issues/cancer_development_signaling.

Thank you for your attention,

Best regards,

Daniela Spano