- Speaker: Valeria Pecce
Dep. of Translational and Precisione Medicine
- Title: “Organoids: a new dimension in cell culture models – Bridging basic research and translational medicine”
- Host Researcher : Fabiola Moretti
Abtract
Organoids: a new dimension in cell culture models – Bridging basic research and translational medicine
Organoids have emerged as a transformative paradigm in cell biology, providing three-dimensional, human-relevant models that recapitulate key aspects of tissue architecture, cellular heterogeneity, and functional responses. A PubMed-based historical analysis indicates that organoid research originated in the mid-20th century and experienced a marked resurgence after 2010.
In thyroid biology, induced pluripotent stem cell (iPSC)-derived organoid systems are a key model for studying tissue development and disease mechanisms. Complementary approaches have been developed for thyroid cancer, including simplified organoid models designed to reduce technical complexity while preserving biological relevance and functional readouts. Among the most relevant applications of these systems is the REPorg system platform, a modular organoid-based technology that integrates inducible fluorescent reporters to dynamically monitor major cellular signaling pathways in response to pharmacological treatments.
This seminar presents an integrated overview of organoid technology applied to thyroid research, from historical foundations to recent methodological innovations, highlighting strategies that enhance experimental accessibility, functional relevance, and translational potential.
