We are interested in understanding the cell biological basis of physiology and pathology. We do this by studying the Golgi apparatus.
The major themes currently under investigation in our lab are:
- Regulation of glycosylation: We are studying how the Golgi controls glycosylation of cargoes passing through the organelle to regulate cell physiology and cancer.
- Regulation of palmitoylation: Golgi apparatus is the major station for palmitoylation in the cell. We are studying how palmitoylation reactions are controlled in the Golgi and how this might contribute to neurodegenerative disorders.
- Tissue specific regulation of Golgi apparatus: Golgi apparatus morphology and function varies widely between tissues. We are starting a study on the molecular basis of this differentiation and how it contributes to tissue functions.
- Golgi and oncogenesis: We are analyzing large scale genomic and transcriptomic data to identify novel oncoproteins localized to the Golgi apparatus
- Golgi interactome: We are building the interactome network of Golgi localized proteins to understand their modular organization and how Golgi modules interact with other cellular functional modules.
PhD, National Institute of Immunology, India
Post-doctoral Fellow, Mario Negri Sud Insitute, Italy
Post-doctoral Fellow, TIGEM, Italy
Kinase and ubiquitin ligase inhibitors and uses thereof. (No. 102015000084815), 2015
- Regulated compartmentalization of enzymes in Golgi by GRASP55 controls cellular glycosphingolipid profile and function. Pothukuchi P et al 2020 BioRxiv
- Translation of genome to glycome: role of the Golgi apparatus. Pothukuchi P, Agliarulo I, Russo D, Rizzo R, Russo F, Parashuraman S.FEBS Lett. 2019 93(17):2390-2411.
- Visualizing sphingolipid biosynthesis in cells. Parashuraman S, D’Angelo G. Chem Phys Lipids. 2019 218:103-111.
- Unravelling druggable signalling networks that control F508del-CFTR proteostasis. Hegde RN, Parashuraman S, Iorio F, Ciciriello F, Capuani F, Carissimo A, Carrella D, Belcastro V, Subramanian A, Bounti L, Persico M, Carlile G, Galietta L, Thomas DY, Di Bernardo D, Luini A. Elife 2015 4:e10365.
- Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae. Beznoussenko GV, Parashuraman S, Rizzo R, Polishchuk R, Martella O, Di Giandomenico D, Fusella A, Spaar A, Sallese M, Capestrano MG, Pavelka M, Vos MR, Rikers YG, Helms V, Mironov AA, Luini A. Elife. 2014 ;3:e02009.
- Signaling at the Golgi: sensing and controlling the membrane fluxes.
Luini A, Parashuraman S. Curr Opin Cell Biol. 2016 ;39:37-42.