Marinella Pirozzi

Research Areas: Euro-bioimaging infrastructure, Advanced morphology, Mammalian secretory pathway

Research Area NA1
+39 081 6232 544 (office)

Keywords: Light and electron microscopy, Correlative microscopy (CLEM), Live imaging, Cell Biology

Marinella Pirozzi, as a microscopy specialist provides all of the Institute investigators with the latest imaging technologies, such as wide-field, fluorescence and confocal microscopy, live imaging, image acquisition, digital image analysis as basic and advanced applications (deconvolution, 3D rendering), and the expertise of using these tools. She provides technical assistance for the use of optical basic and advanced light microscopy instrumentations; provides consultation and training to use the various techniques of light and fluorescence microscopy, image analysis and processing and data transfer and storage; performs independent and collaborative preparations and analysis of specimens for electron microscopy.

  • 2014. Researcher (Ricercatore III fascia), National Research Council – Institute of Protein Biochemistry, Naples, Italy
  • 2007-2014. Staff Responsible of TIGEM Microscopy and Imaging Core, Telethon Institute of Genetic and Medicine, Naples.
  • 2001-2006. Post-doc position at TIGEM, Telethon Institute of Genetic and Medicine, Naples.
  • 2002. PhD in Biochemistry and Molecular Biology. University of Naples “Federico II”.
  • 1996. Master Degree in Biological Sciences, with 110/110 cum laude with a dissertation in Biochemistry, University of Naples “Federico II”.
  • 1991-1996.  Student in Biological Sciences. University of Naples “Federico II”, Naples, Italy

Swartzwelter BJ, Barbero F, Alessandro A, Mangini M, Pirozzi M, De Luca AC, Puntes VF, Leite LCC, Italiani P, Boraschi D. Gold nanoparticles modulate BCG-induced innate immune memory in human monocytes by shifting the memory response towards tolerance. Cells, Jan 23, 10(1), 100 (2020). PMID: 31979412


Di Loria A, Dattilo V, Santoro D, Jacopo Guccione J, De Luca A, Ciaramella P, Pirozzi M, Iaccino E. Expression of serum exosomal miRNA 122 and lipoprotein levels in dogs naturally infected by Leishmania infantum: A Preliminary Study. Animals, Jan 8, 9(2), 284 (2020). PMID: 31936232


Chiritoiu M, Brouwers N, Turacchio G, Pirozzi M, Malhotra V. GRASP55 and UPR control Interleukin-1 aggregation and secretion. Developmental Cell, Apr 8, 49:145–155 (2019). PMID: 30880003


Subramanian A, Capalbo A, Iyengar NR, Rizzo R, di Campli A, Lo Monte M, Beccari A, Yerudkar A, del Vecchio C, Glielmo L, Turacchio G, Pirozzi M, Kim SG, Henklein P, Cancino J, Parashuraman S, Diviani D, Fanelli F, Sallese M, Luini A. Auto-regulation of secretory flux by sensing and responding to the folded cargo protein load in the endoplasmic reticulum. CELL Mar 7; 176(6): 1461-1476 (2019). PMID: 30849374


Schiavon CR, Griffin ME, Pirozzi M, Parashuraman R, Zhou W, Jinnah HA, Reines D, Kahn RA. Compositional complexity of rods and rings. Mol Biol Cell. 2018 Sep 15, 29 (19): 2303-2316 (2018). Epub 2018 Jul 19. PMID: 30024290


Schiattarella GG, Cattaneo F, Carrizzo A, Paolillo R, Boccella N, Ambrosio M,Damato A, Pironti G, Franzone A, Russo G, Magliulo F, Pirozzi M, Storto M, Madonna M, Gargiulo G, Trimarco V, Rinaldi L, De Lucia M, Garbi C, Feliciello A, Esposito G, Vecchione C, Perrino C. Akap1 Regulates Vascular Function andEndothelial Cells Behavior. Hypertension. Mar 71(3): 507-517 (2018). PMID: 29335250


Cicatiello P, Dardano P, Pirozzi M, Gravagnuolo AM, De Stefano L, Giardina P. Self-assembly of two hydrophobins from marine fungi affected by interaction with surfaces. Biotechnol Bioeng. Oct, 114 (10): 2173-2186 (2017). PMID: 28543036


Capasso S, Sticco L, Rizzo R, Pirozzi M, Russo D, Dathan NA, Campelo F, van Galen J, Hölttä‐Vuori M, Turacchio G, Hausser A, Malhotra V, Riezman I, Riezman H, Ikonen E, Luberto C, Parashuraman S, Luini A and D’Angelo G. Sphingolipid metabolic flow controls phosphoinositide turnover at the trans‐Golgi network. EMBO J. May 2, 36 (9): 1117–1297 (2017). PMID: 28495678


Raote I, Ortega Bellido M, Pirozzi M, Zhang C, Melville D, Parashuraman S, Zimmermann T, Malhotra V. TANGO1 assembles into rings around COPII coats at ER exit sites. J Cell Biol. Mar 9, 216 (3) (2017). PMID: 28280121


Schiattarella GG, Cattaneo F, Pironti G, Magliulo F, Carotenuto G, Pirozzi M, Polishchuk R, Borzacchiello D, Paolillo R, Oliveti M, Boccella N, Avvedimento M, Sepe M, Esposito G, Trimarco B, Feliciello A, Perrino C. Akap1 deficiency promotes mitochondrial aberrations and exacerbates cardiac injury following permanent coronary ligation via enhanced mitophagy and apoptosis. PLoS One. May 2, 11 (5) (2016). PMID: 27136357


Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, Cecconi F, Grumati P and Bonaldo P. Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy. Nov, 11 (12): 2142-52 (2015). PMID: 26565691


Avellino R, Carrella S, Pirozzi M, Risolino M, Salierno FG, Franco P, Stoppelli P, Verde P, Banfi S, Conte I. miR-204 targeting of Ankrd13A controls both mesenchymal neural crest and lens cell migration. PLoS One. Apr, 8 (4) (2013). Epub 2013 Apr 19.
PMID: 23620728

Alfano C, Viola L, Heng JI, Pirozzi M, Clarkson M, Flore G, De Maio A, Schedl A, Guillemot F, Studer M. COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.  Development. Nov, 138 (21): 4685-97 (2011). Epub 2011 Sep 28. PMID: 21965613


Bizzarro V, Fontanella B, Franceschelli S, Pirozzi M, Christian H, Parente L, Petrella A. Role of Annexin A1 in mouse myoblast cell differentiation. J Cell Physiol. Sep, 224 (3): 757-765 (2010). PMID: 20578244


Tessitore A, Pirozzi M, Auricchio A. Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of Mucopolysaccharidosis VI. PathoGenetics, 2 (4): (2009). PMID: 19531206


Pirozzi M, Quattrini A, Andolfi G, Auricchio A, Rugarli EI. Long-term rescue of axonal degeneration and motor performance by viral intramuscular delivery of paraplegin in a mouse model for hereditary spastic paraplegia. J Clin Invest. Jan, 116 (1): 202-208 (2006). Epub 2005 Dec 15. PMID: 16357941


Duilio A, Madonna S, Tutino ML, Pirozzi M, Sannia G, Marino G. Promoters from a cold-adapted bacterium: definition of a consensus motif and molecular characterization of UP regulative elements. Extremophiles. Apr, 8 (2): 125-132 (2004). PMID: 15064979


Ferreirinha F, Quattrini A, Pirozzi M, Valsecchi V, Dina G, Broccoli V, Auricchio A, Piemonte F, Tozzi G, Gaeta L, Casari G, Ballabio A, Rugarli EI. Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. J Clin Invest. Jan, 113 (2): 231-242 (2004). PMID: 14722615