Alessia Varone

Research Area: ?


Napoli Research Area NA1
+39 06 90091578 (office)
+39 06 90091494 (lab)
alessia.varone@ibbc.cnr.it

Within Daniela Corda’s laboratory, my specific interests are in the field of lipid signaling, at the crossroads between lipid metabolism and cellular signaling.  My research focuses on the study of the glycerophosphoinositols, as bioactive and water-soluble metabolites of membrane phosphoinositides. The glycerophosphoinositols represent a novel class of second messengers that control a wide range of cellular functions by regulating diverse signaling pathways. 
We are currently studying the role of these compounds in immune and ­­inflammatory responses and in the regulation of cancer progression, with the aim of exploiting their promising therapeutic potential for the development of new drugs.

Education:

  • 2012 PhD Open University, Milton Keynes – Consorzio “Mario Negri” Sud (Santa Maria Imbaro) and Telethon Institute for Genetics and Medicine (TIGEM, Naples)
  • 2006 Master Degree in Medical Biotechnology, University of Naples “Federico II” (Naples)
  • 2004 Bachelor Degree in Biotechnology, University of Naples “Federico II” (Naples)

 

 

Positions:

  • 2014-present Researcher at Institute of Protein Biochemistry – National Research Council of Italy (IBP-CNR), Naples
  • 2012-2014 PostDoc at the IBP-CNR Institute, Naples
  • 2010-2012 Doctoral Fellowship at Telethon Institute for Genetics and Medicine (TIGEM), Naples
  • 2007-2009 Doctoral Fellowship at Consorzio “Mario Negri” Sud, Santa Maria Imbaro
  • 2006-2007 pre-Doctoral Fellowship at Consorzio “Mario Negri” Sud, Santa Maria Imbaro
  • 2004-2006 Undergraduate Research trainee. Dept. of Biochemistry and Medical Biotechnology (DBBM), University of Naples “Federico II”, Naples

 

Honours/Awards:

  • 2010-2012: 3 years Fellowship from the Italian Federation for Cancer Research (FIRC, Milan, Italy).

    Winner of several Young Travel Grants (YTG):
  • 2008: YTG for the FEBS Workshop on “Lipids as regulators of cell function”, Spetses.
  • 2009: YTG for the 9th Young Scientist Forum and 34th FEBS Congress on “Life’s Molecular Interaction”, Prague.
  • 2010: YTG for the 35th FEBS Congress on “Molecules of Life”, Gothenburg.
  • 2013: YTG for the 38th FEBS Congress on “Mechanisms in Biology”, St. Petersburg.
  • A signalling cascade involving receptor-activated phospholipase A2, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility.
    Varone A, Mariggiò S, Patheja M, Maione V, Varriale A, Vessichelli M, Spano D, Formiggini F, Lo Monte M, Brancati N, Frucci M, Del Vecchio P, D’Auria S, Flagiello A, Iannuzzi C, Luini A, Pucci P, Banci L, Valente C and Corda D. Cell Commun Signal. (2019) Mar 1;17(1):20.
  • The natural phosphoinositide-derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses.
    Vessichelli M, Mariggiò S, Varone A, Zizza P, Di Santo A, Amore C, Dell’Elba G, Cutignano A, Fontana A, Cacciapuoti C, Di Costanzo G, Zannini M, de Cristofaro T, Evangelista V, Corda D.
    J Biol Chem. (2017) Aug 4; 292(31):12828-12841.
  • Automatic quantification of the extracellular matrix degradation produced by tumor cells.
    Brancati N, De Pietro G, Frucci M, Amoruso C, Corda D, Varone A.
    Innovation in Medicine and Healthcar, Spinger International Publishing (2016), 137-145.
  • The glycerophosphoinositols and their cellular functions.
    Corda D, Zizza P, Varone A, Bruzik KS, Mariggiò S. Biochem Soc Trans. (2012) 40(1), 101-7.
  • The glycerophosphoinositols: cellular metabolism and biological functions.
    Corda D, Zizza P, Varone A, Filippi BM and Mariggiò S. Cell Mol Life Sci. (2009) 66, 3449-67.