Cell and molecular biology: intracellular signaling and trafficking
Several cell biology groups at the IBBC have traditionally worked in two overlapping areas of cell biology, namely, signal transduction and intracellular membrane transport. The general objective is to investigate at the molecular level basic biological processes and exploit this knowledge to design novel drug-based therapies, and novel diagnostic approaches, in the fields of cancer and rare diseases.
Specifically, the main research areas of these groups are:
- Metabolism of the glycerophosphoinositols and of phosphatidic acid, G-protein-coupled receptors, and the ADP-ribosylation reaction; the general aim is to elucidate the cellular regulatory mechanisms that, when defective, lead to rare diseases and cancer.
- Development of strategies, cellular models, and technologies (including imaging and systems biology approaches) for the investigation of the organizational principles and regulation of cargo transport across membrane compartments; pharmacological approaches for diseases related to membrane transport.
- Structure and function of intracellular organelles during cell division and their role in the regulation of cell cycle, with implications in the definition of novel drug-based strategies to inhibit proliferation of cancer cells.
- Develop advanced optical technologies based on Raman Spectroscopy to provide novel and reliable procedures for label-free characterization of single cells and single molecules.
Groups involved :
Lab of “Cell Regulation”
Lab of “Morpho-functional organization and regulation of the biosynthetic pathway”
Lab of “The Golgi Mitotic Checkpoint”
Lab of “Cell Biology and Membrane Dynamics”
Lab of “Organization and function of the mammalian secretory pathway
Lab of “Lysophospholipid Signalling for the Development of new Therapeutic Strategies”
Lab of “Biophotonics and advanced microscopies”